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The Effects of Furosemide and Hypoxia on CIick-Evoked Otoacoustic Emissions in Anesthetized Guinea Pigs

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Authors
Chang, Sun O; Jung, Ha Won
Issue Date
1993-06
Publisher
Seoul National University College of Medicine
Citation
Seoul J Med, Vol.34 No.2, pp. 139-145
Keywords
FurosemideHypoxiaClickEvoked otoacoustic emissionGuinea pig
Abstract
From the concepts of well known ototoxic effects of loop diuretics
and hypoxic state, twenty anesthetized guinea pigs with diuretics and/or hypoxia
were evaluated with click-evoked otoacoustic emissions (CEOAEs) by timesequential
monitoring. Furosemide 25 mg/kg was infused intravenously and
CEOAEs were measured before and 5, 10, 20, 30, 45 and 60 minutes after
injection in 8 guinea pigs. Both echo responses and reproducibilities were
decreased significantly at 10 minutes after injection and showed minimal level at
20 minutes. Recovery of CEOAEs was noted by spectral analysis at 30 minutes
after injection, and full recovery of CEOAEs was evident after then. At 60
minutes after injection, hypoxia of 20 seconds by turning off the artificial
respirator was added. The CEOAEs showed statistically significant decreases
compared with those of prehypoxic state (pwith injection of furosemide. 50 mg/kg showed decreased responses and no
fr
recoveries for the 60 minutes observation periods. Findings from this study
support the clinical utility of CEOAEs as a screening test for early detection of
various ototoxicities.
ISSN
0582-6802
Language
English
URI
https://hdl.handle.net/10371/5582
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College of Medicine/School of Medicine (의과대학/대학원)Dept. of Medicine (의학과)The Seoul Journal of MedicineThe Seoul Journal of Medicine Vol. 34 No.2 (1993)
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