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Effect of Red Pepper and Bracken Fern on GastroduodenaI Carcinogenesis in Wistar Rats Induced by N-MethyI-N'-nitro-N-nitrosoguanidine
DC Field | Value | Language |
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dc.contributor.author | Park, Kyung-Hwan | - |
dc.contributor.author | Kim, Jin-Pok | - |
dc.date.accessioned | 2009-07-14T23:03:16Z | - |
dc.date.available | 2009-07-14T23:03:16Z | - |
dc.date.issued | 1993-06 | - |
dc.identifier.citation | Seoul J Med, Vol.34 No.2, pp. 117-125 | - |
dc.identifier.issn | 0582-6802 | - |
dc.identifier.uri | https://hdl.handle.net/10371/5586 | - |
dc.description.abstract | Epidemiologic and experimental studies have shown that gastric
carcinogenesis is strongly associated with dietary habits. This experiment was performed to analyze the effects of red pepper and bracken fern on gastroduodenal carcinogenesis by N-methyl-N' -nitro-N-nitrosoguanidine (MNNG) in vivo. Male Wistar rats were divided into 6 groups: control group (A), red pepper only treated group (8), bracken fern only treated group (C), MNNG only treated group (0), MNNG and red pepper treated group (E) and MNNG and bracken fern treated group (F). The control group was supplied with a normal diet and distilled water. MNNG was given at a concentration of 100 Jig/ml in distilled water for 0, E and F groups, supplemented with 3% red pepper for E group and supplemented with 5% bracken fern for F group. Three percent red pepper in diet was given to 8 group and five percent bracken fern in diet was given to C group. These diet regimens were given ad libitum continuously for 40 weeks. Histopathological examination was performed after 40 weeks of experiment. Tumors occurred only in MNNG administered groups. There were no differences in the occurrence rates of adenocarcinoma of the glandular stomach between 0, E and F group (78.3%, 70.8%, 73.9%). There was a significantly higher occurrence rate of adenocarcinoma of the duodenum in E and F groups (41.7%, 30.4%) than in the 0 group (4.3%) (P<0.05). These results suggest that red pepper and bracken fern have a promoting effect on duodenal carcinogenesis by MNNG. | - |
dc.language.iso | en | - |
dc.publisher | Seoul National University College of Medicine | - |
dc.subject | Chemical carcinogenesis | - |
dc.subject | MNNG | - |
dc.subject | Red pepper | - |
dc.subject | Bracken fern | - |
dc.title | Effect of Red Pepper and Bracken Fern on GastroduodenaI Carcinogenesis in Wistar Rats Induced by N-MethyI-N'-nitro-N-nitrosoguanidine | - |
dc.type | SNU Journal | - |
dc.contributor.AlternativeAuthor | 박경환 | - |
dc.contributor.AlternativeAuthor | 김진복 | - |
dc.citation.journaltitle | 서울 의대 잡지 | - |
dc.citation.journaltitle | 서울 의대 학술지 | - |
dc.citation.journaltitle | Seoul Journal of Medicine | - |
dc.citation.endpage | 125 | - |
dc.citation.number | 2 | - |
dc.citation.pages | 117-125 | - |
dc.citation.startpage | 117 | - |
dc.citation.volume | 34 | - |
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