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Comparative Study for the Differentiation of Allergic and Irritant Contact Dermatitis in Mice
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- Authors
- Issue Date
- 1993-03
- Citation
- Seoul J Med, Vol.34 No.1, pp. 49-54
- Keywords
- Allergic and irritant contact dermatitis ; BALB/c mice ; Langerhans cells ; Ear swelling ; la (+) keratinocytes
- Abstract
- Our study was performed to compare the differences between
allergic and irritant contact dermatitis in BALB/c mice. Allergic reaction was
induced by a sensitizing regimen of 2,4-dinitro-l-fluorobenzene (DNFB) and
irritant reaction by 10% sodium lauryl sulfate (SLS). The following differences
were noted: 1) the mice with irritant reaction showed an earlier peak of ear
swelling, 2) increasing number of Langerhans cells (LCs) in allergic reaction but
decreasing number of LCs in irritant reaction was observed at 48 hr after
challenge of DNFB or SLS, and 3) induction of Ia (+) keratinocytes was found
only in allergic reaction. It was suggested that Ia (+) keratinocytes play an active
role in the mechanism of allergic contact dermatitis.
- ISSN
- 0582-6802
- Language
- English
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