S-Space College of Medicine/School of Medicine (의과대학/대학원) Dept. of Medicine (의학과) The Seoul Journal of Medicine The Seoul Journal of Medicine Vol. 30 No.4 (1989)
An Analysis of Diseases Associated with Eosinophilia In Childhood
소아에서 호산구증다증을 동반하는 질환
- Kim, Joong Gon; Ahn, Hyo Seop
- Issue Date
- Seoul J Med, Vol.30 No.4, pp. 249-255
- We analyzed 500 children who had eosinophils comprising more than 6% of
the circulating leukocytes in their blood and more than 250 eosinophils per cubic millimeter
for the causal diseases of or the conditions associated with eosinophilia.
Eosinophilia was mainly observed in patients with drug reactions (lOS cases), allergic
diseases (78 caes) or malignant diseases (60 cases). Drug reactions were caused by penicillin
analogues (76 cases) or anti-convulsants, especially carbamazepine (29 cases). Allergic diseases
included asthma (36 cases), allergic rhinitis (25 cases), brain tumors (8 cases), nonHodgkin's
lymphomas (7 cases), Hodgkin's diseases (3 cases), acute myeloblastic leukemia (2
cases) or sarcoma (15 cases).
Eosinophils comprising more than 20% of the circulating leukocytes were mainly observed
in patients with allergic diseases (38%), malignant disseases (19%) or durg reactions (13%).
It can be concluded that eosinophilia in childhood is mainly associated with allergic diseases,
malignant diseases or drug reactions, and of these three causes drug reaction is the
most frequent one.