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Pharmacokinetic Approaches for the Optimum Phenytoin Administration
Phenytoin의 적정복용량 결정을 위한 약력학적 분석에 관한 연구

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Authors
Myung, Ho-Jin; Park, Chan-Woong; Shin, Sang-Goo; Lee, Kwang-Woo
Issue Date
1985-03
Publisher
Seoul National University College of Medicine
Citation
Seoul J Med, Vol.26 No.1, pp. 88-95
Keywords
PhenytoinPharmacokineticDosage adjustmentMichaelis-Menten kineticDirect-linear plot
Abstract
A rapid and reliable approach in achieving an optimum individual phenytoin
dosage regimen using appropriate population pharmacokinetic parameters was described. A
simple graphic technique to obtain an accurate individualization of dosage regimen was also
suggested.
Steady state serum phenytoin concentrations were measured in 41 patients at 3 or 4
maintenance dose levels. A rapid technique for individualization of dosage adjustment was
constructed using in vivo Vma x and Km values based on Michaelis-Menten kinetics. Its reliability
was evaluated by comparison with other reported techniques.
At dosage adjusted by the technique using steady state serum phenytoin concentration with
initial maintenance dose and population Vmax based on body weight, there was highly significant
correlation between observed and predicted serum concentrations(r=O.66, pThe results suggested that population Vmax based on age could be utilized in a rapid
technique for optimum phenytoin dosage adjustment and that the efficiency of the adjustment
will be further improved by application of the direct -linear plot technique.
ISSN
0582-6802
Language
English
URI
http://hdl.handle.net/10371/5677
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College of Medicine/School of Medicine (의과대학/대학원)Dept. of Medicine (의학과)The Seoul Journal of MedicineThe Seoul Journal of Medicine Vol. 26 No.1 (1985)
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