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Chemotherapy of Human Colon Cancer Transplanted in Nude Mouse : 누드 마우스에 이식된 인체대장암에 대한 화학요법
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- Authors
- Issue Date
- 1987-03
- Citation
- Seoul J Med, Vol.28 No.1, pp. 28-35
- Keywords
- Chemotherapy ; Human colon cancer transplanted ; Nude mouse
- Abstract
- Human colon carcinomas, transplantable in BALB/c nude mice, designated as
SCN-l, SCN-2 and SCN-4, were serially passed for 8, 12 and 8 generations respectively. A
piece of each tumor excised to 2 mm in diameter was inoculated subcutaneously on the back
of nude mice. Experimental chemotherapies with a single drug, adriamycin, mitomycin C or
5-fluorouracil were started when the tumors reached 5-6 mm in diameter. The results showed
that mitomycin C and 5-fluorouracil significantly suppressed the growth of colon cancer. The
histologic features of transplanted tumor were similar to those of the original tumors.
- ISSN
- 0582-6802
- Language
- English
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