S-Space College of Medicine/School of Medicine (의과대학/대학원) Dept. of Medicine (의학과) The Seoul Journal of Medicine The Seoul Journal of Medicine Vol. 26 No.2 (1985)
Immunofluorescent Findings in Graves' Disease and Hashimoto's Disease
Graves 및 Hashimoto병에서의 면역형광소견
- Ahn, Il-Min; Cho, Bo Youn; Koh, Chang-Soon; Lee, Munho; Park, Seoung Hoe; Kim, Yong Il
- Issue Date
- Seoul J Med, Vol.26 No.2, pp. 149-156
- Direet immunofluorescent study with antisera against Ig G, A, M, C3 & fibrinogen
was performed on thyroid specimens from 21 cases of Graves' disease and 11 cases of
Hashimoto's thyroiditis to define immunofluorescent findings in each disorder and their functional
significance, with the following results;
1. Ninety five % of Graves' disease cases showed significant granular immunofluorescent
deposit along follicular basement menbrane and remainder showed scanty granular deposit on
2. Forty five % of Hashimoto's thyroiditis cases showed immunofluorescent deposit along
follicular basement membrane, whereas 63% showed deposition on interfollicular space.
3. Three cases histologically appreciated as Hashimoto's thyroiditis had significant deposit
along follicular basement membrane, and all of them showed physical findings and past
history compatible with Graves' disease.
4. 'there was no significant correlation between immunofluorescent deposit, and thyroid
function or the presence of thyroid autoantibodies.
5. Comparing immunofluorescent studies with light microscopic findings, degree of immunofluorescent
deposit along follicular basement membrane was correlated well with the
degree of lymphocytic infiltration in Graves' disease.
In this study, it was shown that the pattern of immunofluorescent deposition in Graves'
disease was different from that of Hashimoto's disease, and the degree of immunofluorescent
deposit along follicular basement membrane was correlated well with the degree of lymphocytic
infiltration in Graves' disease.