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Association of human leukocyte antigen-DRB1 alleles with disease susceptibility and severity of aplastic anemia in Korean patients

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dc.contributor.authorSong, Eun Young-
dc.contributor.authorPark, Soyun-
dc.contributor.authorLee, Dong Soon-
dc.contributor.authorCho, Han Ik-
dc.contributor.authorPark, Myoung Hee-
dc.date.accessioned2010-03-09T05:34:52Z-
dc.date.available2010-03-09T05:34:52Z-
dc.date.issued2008-06-24-
dc.identifier.citationHum Immunol. 2008 Jun;69(6):354-9. Epub 2008 May 16.en
dc.identifier.issn0198-8859 (Print)-
dc.identifier.issn0198-8859 (Linking)-
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=18571007-
dc.identifier.urihttp://www.sciencedirect.com/science?_ob=MImg&_imagekey=B6T3B-4SHN8P7-1-1&_cdi=4942&_user=168665&_orig=search&_coverDate=06%2F30%2F2008&_sk=999309993&view=c&wchp=dGLbVtb-zSkzV&md5=96e004255e8e5a5e27f7eb0a05c0fdfe&ie=/sdarticle.pdf-
dc.identifier.urihttp://www.sciencedirect.com/science?_ob=MImg&_imagekey=B6T3B-4SHN8P7-1-1&_cdi=4942&_user=168665&_orig=search&_coverDate=06%2F30%2F2008&_sk=999309993&view=c&wchp=dGLbVtb-zSkzk&md5=96e004255e8e5a5e27f7eb0a05c0fdfe&ie=/sdarticle.pdf-
dc.identifier.urihttps://hdl.handle.net/10371/58515-
dc.description.abstractAlthough association of human leukocyte antigen (HLA)-DR2 (DRB1*1501) with susceptibility to aplastic anemia (AA) has been well documented in several different ethnic groups, little is known about the protective role of HLA in this disease. HLA-DRB1 alleles were analyzed in 109 Korean AA patients (26 nonsevere and 83 severe) and 800 healthy controls. The frequency of DRB1*1501 was significantly higher in AA patients compared with controls [33.0% vs 15.3%, p=0.000004, p(c)=0.0001, odds ratio (OR)=2.74]. Nonsevere AA (30.8%, OR=2.47) and severe AA patients (33.7%, OR=2.83) showed similar changes, and DRB1*1501 was considered a susceptibility factor to AA in both forms of the disease. The frequency of DRB1*1302 in total AA patients was not different from controls (12.8% vs 17.9%), but it was significantly lower in severe AA compared with nonsevere AA patients (6.0% vs 34.6%, p=0.0006, p(c)=0.02, OR=0.12). DRB1*1302 was considered a protective factor against severe AA. In Koreans, DRB1*1501 was associated with disease susceptibility to AA and DRB1*1302 with protection against the severe form of the disease.en
dc.language.isoenen
dc.publisherElsevieren
dc.subjectAdolescenten
dc.subjectAdulten
dc.subjectAgeden
dc.subjectAged, 80 and overen
dc.subjectAnemia, Aplastic/blood/*genetics/immunology/physiopathologyen
dc.subjectChilden
dc.subjectChild, Preschoolen
dc.subjectFemaleen
dc.subjectGenetic Predisposition to Diseaseen
dc.subjectHLA-DR Antigens/blood/*genetics/immunologyen
dc.subjectHumansen
dc.subjectInfanten
dc.subjectKoreaen
dc.subjectMaleen
dc.subjectMiddle Ageden
dc.subjectSeverity of Illness Indexen
dc.subjectAsian Continental Ancestry Group-
dc.subjectGene Frequency-
dc.titleAssociation of human leukocyte antigen-DRB1 alleles with disease susceptibility and severity of aplastic anemia in Korean patientsen
dc.typeArticleen
dc.contributor.AlternativeAuthor송은영-
dc.contributor.AlternativeAuthor박소연-
dc.contributor.AlternativeAuthor이동순-
dc.contributor.AlternativeAuthor조한익-
dc.contributor.AlternativeAuthor박명희-
dc.identifier.doi10.1016/j.humimm.2008.04.009-
Appears in Collections:
College of Medicine/School of Medicine (의과대학/대학원)Laboratory Medicine (검사의학전공)Journal Papers (저널논문_검사의학전공)
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