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Risk of recurrence in surgically resected stage I adenocarcinoma of the lung: histopathologic and immunohistochemical analysis

Cited 13 time in Web of Science Cited 14 time in Scopus
Authors
Cho, Sukki; Sung, Sook-Whan; Jheon, Sanghoon; Chung, Jin-Haeng
Issue Date
2008-10-07
Publisher
Springer Verlag
Citation
Lung. 2008 Nov-Dec;186(6):411-9. Epub 2008 Oct 4.
Keywords
Adenocarcinoma/chemistry/*pathologyAgedCadherins/*analysisDisease-Free SurvivalFemaleFollow-Up StudiesHumansImmunohistochemistryKi-67 Antigen/*analysisLung Neoplasms/chemistry/*pathologyMaleMiddle AgedMultivariate AnalysisNeoplasm Recurrence, Local/chemistry/*pathologyPrognosisProportional Hazards ModelsRecurrenceRiskTumor Markers, Biological/analysisTumor Suppressor Protein p53/*analysis
Abstract
STUDY OBJECTIVES: Stage I adenocarcinoma of the lung is the most common type of lung cancer. A better understanding of the histopathology and molecular biology of lung cancer might improve the capability to predict the outcome for any individual patient. The purpose of this study was to evaluate several histopathologic and molecular markers in order to assess their prognostic value in stage I adenocarcinoma. METHODS: Fifty-five patients at the Seoul National University Bundang Hospital were enrolled in the study. Histopathologic factors and molecular markers were selected. RESULTS: Multivariate analysis demonstrated that necrosis, lymphatic vessel invasion, E-cadherin, p53, and Ki-67 emerged as independent prognostic factors of recurrence. When patients were grouped according to low or high risk according to the number of factors involved, the difference in disease-free survival between these groups was statistically significant. CONCLUSIONS: In resected stage I adenocarcinoma, necrosis, lymphatic vessel invasion, E-cadherin, and p53 have been identified as independent predictors of disease-free survival.
ISSN
0341-2040 (Print)
Language
English
URI
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=18836777

http://www.springerlink.com/content/k6128q0254v73583/fulltext.pdf

https://hdl.handle.net/10371/60097
DOI
https://doi.org/10.1007/s00408-008-9116-4
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College of Medicine/School of Medicine (의과대학/대학원)Thoracic Surgery (흉부외과학전공)Journal Papers (저널논문_흉부외과학전공)
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