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EGFR gene copy number in adenocarcinoma of the lung by FISH analysis: investigation of significantly related factors on CT, FDG-PET, and histopathology

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dc.contributor.authorPark, Eun-Ah-
dc.contributor.authorLee, Hyun Ju-
dc.contributor.authorKim, Young Tae-
dc.contributor.authorKang, Chang Hyun-
dc.contributor.authorKang, Keon Wook-
dc.contributor.authorJeon, Yoon Kyung-
dc.contributor.authorGoo, Jin Mo-
dc.contributor.authorLee, Chang Hyun-
dc.contributor.authorPark, Chang Min-
dc.date.accessioned2010-03-24T06:48:30Z-
dc.date.available2010-03-24T06:48:30Z-
dc.date.issued2008-09-30-
dc.identifier.citationLung Cancer 2009;64:179–186en
dc.identifier.issn1872-8332 (Electronic)-
dc.identifier.urihttps://hdl.handle.net/10371/61887-
dc.description.abstractIt has been suggested that a high EGFR gene copy number may be an indicator of good response to EGFR tyrosine kinase inhibitor therapy and a marker of poor prognosis in NSCLC. However, imaging features related to EGFR gene copy number status in adenocarcinoma are still unknown. We therefore retrospectively analyzed CT, FDG-PET, and histopathologic slides of surgical resected lung adenocarcinoma in 132 patients. Tumor characteristics on preoperative chest-CT, such as, GGO proportions, tumor diameters, and cavitation; FDG-PET SUV(max); and histopathologically determined differentiation degrees and tumor subtypes were evaluated. EGFR gene copy number status was categorized as FISH-positive or -negative. FISH-positivity was found in 53 patients (40.2%) and was significantly more frequent in tumors with a SUV(max)>7.0 (P=0.007). Furthermore, FISH-negativity was found to be more frequent in tumors with a GGO>50% (P=0.023) and diameter <15.5mm (P=0.006) on CT, or a well-differentiated histopathology (P=0.002). Moreover, the frequency of FISH-positivity increased as SUV(max) increased (P=0.0008) and as the proportion of GGO decreased (P=0.01). SUV(max)>7.0 was an independent predictor of FISH-positive results (odds ratio, 3.941; 95% CI, 1.691-9.182; P=0.01). In conclusion, a high SUV(max) on FDG-PET was significantly related to FISH-positive results. A high proportion of GGO, small tumor diameter on CT, and a well-differentiated histopathology were more frequent in FISH-negative adenocarcinomas.en
dc.language.isoenen
dc.publisherElsevieren
dc.subjectAdenocarcinoma/*genetics/*radiography/*radionuclide imagingen
dc.subjectAdulten
dc.subjectAgeden
dc.subjectFemaleen
dc.subjectFluorodeoxyglucose F18/diagnostic useen
dc.subjectGene Dosageen
dc.subjectHumansen
dc.subjectImage Interpretation, Computer-Assisteden
dc.subjectIn Situ Hybridization, Fluorescenceen
dc.subjectLung Neoplasms/*genetics/*radiography/*radionuclide imagingen
dc.subjectMaleen
dc.subjectMiddle Ageden
dc.subjectPositron-Emission Tomographyen
dc.subjectRadiopharmaceuticals/diagnostic useen
dc.subjectReceptor, Epidermal Growth Factor/*geneticsen
dc.subjectRetrospective Studiesen
dc.subjectTomography, X-Ray Computeden
dc.titleEGFR gene copy number in adenocarcinoma of the lung by FISH analysis: investigation of significantly related factors on CT, FDG-PET, and histopathologyen
dc.typeArticleen
dc.contributor.AlternativeAuthor박은아-
dc.contributor.AlternativeAuthor이현주-
dc.contributor.AlternativeAuthor김영태-
dc.contributor.AlternativeAuthor강창현-
dc.contributor.AlternativeAuthor강건욱-
dc.contributor.AlternativeAuthor전윤경-
dc.contributor.AlternativeAuthor구진모-
dc.contributor.AlternativeAuthor이창현-
dc.contributor.AlternativeAuthor박창민-
dc.identifier.doi10.1016/j.lungcan.2008.08.003-
Appears in Collections:
College of Medicine/School of Medicine (의과대학/대학원)Thoracic Surgery (흉부외과학전공)Journal Papers (저널논문_흉부외과학전공)
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