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Disruption of Nfic Causes Dissociation of Odontoblasts by Interfering With the Formation of Intercellular Junctions and Aberrant Odontoblast Differentiation
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, Tae-Yeon | - |
dc.contributor.author | Lee, Dong-Seol | - |
dc.contributor.author | Kim, Hyun-Man | - |
dc.contributor.author | Ko, Jea Seung | - |
dc.contributor.author | Gronostajski, Richard M. | - |
dc.contributor.author | Cho, Moon-Il | - |
dc.contributor.author | Son, Ho-Hyun | - |
dc.contributor.author | Park, Joo-Cheol | - |
dc.date.accessioned | 2010-03-26T07:40:42Z | - |
dc.date.available | 2010-03-26T07:40:42Z | - |
dc.date.issued | 2009-05 | - |
dc.identifier.citation | J Histochem Cytochem 57:469-476 | en |
dc.identifier.issn | 0022-1554 | - |
dc.identifier.uri | https://hdl.handle.net/10371/62039 | - |
dc.description.abstract | We reported previously that Nfic-deficient mice exhibit short and abnormal
molar roots and severely deformed incisors. The objective of this study is to address the mechanisms responsible for these changes using morphological, IHC, and RT-PCR analysis. Nfic-deficient mice exhibited aberrant odontoblasts and abnormal dentin formation in molar roots and the labial crown analog of incisors. The most striking changes observed in these aberrant odontoblasts were the loss of intercellular junctions and the decreased expression of ZO-1 and occludin. As a result, they became dissociated, had a round shape, and lost their cellular polarity and arrangement as a sheet of cells. Furthermore, the dissociated odontoblasts became trapped in dentin-like mineralized tissue, resembling osteodentin in the overall morphology. These findings suggest that loss of the Nfic gene interferes with the formation of intercellular junctions that causes aberrant odontoblast differentiation and abnormal dentin formation. Collectively, these changes in odontoblasts contributed to development of molars with short and abnormal roots in Nfic-deficient mice. | en |
dc.description.sponsorship | This study was supported by RO1-2006-000-10581-0 from
the Basic Research Program of The Korea Science and Engineering Foundation, a Korea Science and Engineering Foundation (KOSEF) grant funded by the Korean government (MOST; M10646010002-06N4601-00210), and a Korea Research Foundation grant funded by the Korean Government (MOEHRD, Basic Research Promotion Fund; KRF-2008- 314-E00214). R.M.G. was supported by National Heart, Lung, and Blood Institute Grant 5R01HL080624. | en |
dc.language.iso | en | en |
dc.publisher | Histochemical Society | en |
dc.subject | Nfic | en |
dc.subject | odontoblast | en |
dc.subject | abnormal dentin | en |
dc.subject | root formation | en |
dc.subject | osteodentin | en |
dc.title | Disruption of Nfic Causes Dissociation of Odontoblasts by Interfering With the Formation of Intercellular Junctions and Aberrant Odontoblast Differentiation | en |
dc.type | Article | en |
dc.contributor.AlternativeAuthor | 이태연 | - |
dc.contributor.AlternativeAuthor | 이동설 | - |
dc.contributor.AlternativeAuthor | 김현만 | - |
dc.contributor.AlternativeAuthor | 고제승 | - |
dc.contributor.AlternativeAuthor | 조문일 | - |
dc.contributor.AlternativeAuthor | 손호현 | - |
dc.contributor.AlternativeAuthor | 박주철 | - |
dc.identifier.doi | 10.1369/jhc.2009.952622 | - |
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