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Usefulness of the whole-blood interferon-gamma release assay for diagnosis of extrapulmonary tuberculosis
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Song, Kyoung-Ho | - |
dc.contributor.author | Jeon, Jae Hyun | - |
dc.contributor.author | Park, Wan Beom | - |
dc.contributor.author | Kim, Sung-Han | - |
dc.contributor.author | Park, Kyoung Un | - |
dc.contributor.author | Kim, Nam Joong | - |
dc.contributor.author | Oh, Myoung-don | - |
dc.contributor.author | Kim, Hong Bin | - |
dc.contributor.author | Choe, Kang Won | - |
dc.date.accessioned | 2010-03-31T06:12:00Z | - |
dc.date.available | 2010-03-31T06:12:00Z | - |
dc.date.issued | 2008-12-17 | - |
dc.identifier.citation | Diagn Microbiol Infect Dis. 2009;63(2):182-7. | en |
dc.identifier.issn | 1879-0070 (Electronic) | - |
dc.identifier.uri | https://hdl.handle.net/10371/62215 | - |
dc.description.abstract | The whole-blood interferon-gamma enzyme-linked immunosorbent assay (QuantiFERON-TB Gold [QFT-G]; Cellestis, Carnegie, Australia) has been studied mainly for diagnosing active pulmonary tuberculosis (TB) or latent TB. We prospectively evaluated its diagnostic usefulness in patients suspected with extrapulmonary TB (EP-TB). Of the 100 adult patients with suspected EP-TB, 43 were classified as "confirmed" EP-TB and 5 as "probable" EP-TB. Of the 48 with EP-TB, 27 (56%) were diagnosed with TB lymphadenitis and 11 (17%) with skeletal TB. The overall sensitivity and specificity of the assay were 69% (95% confidence interval [CI(95)], 53-81%) and 82% (CI(95), 69-91%), respectively. Among 44 patients presented with cervical lymphadenopathy, the QFT-G assay showed 86% (CI(95), 64-97%) sensitivity and 87% (CI(95), 66-97%) specificity, whereas in 28 with skeletal involvement, the sensitivity and specificity of the assay were 45% (CI(95), 17-77%) and 81% (CI(95), 54-96%), respectively. These suboptimal diagnostic performances suggest that the QFT-G assay alone is not sufficient for the diagnosis of EP-TB. | en |
dc.language.iso | en | en |
dc.publisher | Elsevier | en |
dc.subject | Adolescent | en |
dc.subject | Adult | en |
dc.subject | Aged | en |
dc.subject | Aged, 80 and over | en |
dc.subject | Enzyme-Linked Immunosorbent Assay/*methods | en |
dc.subject | Female | en |
dc.subject | Humans | en |
dc.subject | Interferon-gamma/*blood | en |
dc.subject | Male | en |
dc.subject | Middle Aged | en |
dc.subject | Mycobacterium tuberculosis/genetics/isolation & purification | en |
dc.subject | Polymerase Chain Reaction | en |
dc.subject | Predictive Value of Tests | en |
dc.subject | Reagent Kits, Diagnostic | en |
dc.subject | Sensitivity and Specificity | en |
dc.subject | Tuberculosis/*diagnosis/*immunology/microbiology | en |
dc.subject | Tuberculosis, Lymph Node/diagnosis/immunology/microbiology | en |
dc.title | Usefulness of the whole-blood interferon-gamma release assay for diagnosis of extrapulmonary tuberculosis | en |
dc.type | Article | en |
dc.contributor.AlternativeAuthor | 송경호 | - |
dc.contributor.AlternativeAuthor | 전재현 | - |
dc.contributor.AlternativeAuthor | 박완범 | - |
dc.contributor.AlternativeAuthor | 김성한 | - |
dc.contributor.AlternativeAuthor | 박경운 | - |
dc.contributor.AlternativeAuthor | 김남중 | - |
dc.contributor.AlternativeAuthor | 오명돈 | - |
dc.contributor.AlternativeAuthor | 김홍빈 | - |
dc.contributor.AlternativeAuthor | 최강원 | - |
dc.identifier.doi | 10.1016/j.diagmicrobio.2008.10.013 | - |
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