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Association between microsatellite polymorphisms in intron II of the human Toll-like receptor 2 gene and nontuberculous mycobacterial lung disease in a Korean population

Cited 31 time in Web of Science Cited 32 time in Scopus
Authors
Yim, Jae-Joon; Kim, Hee Jung; Kwon, O Jung; Koh, Won-Jung
Issue Date
2008-07-08
Publisher
Elsevier
Citation
Hum Immunol. 2008 ;69(9):572-6.
Keywords
AdultAgedAged, 80 and overAllelesFemaleGene FrequencyGenetic Predisposition to DiseaseGenotypeHumansKorea/epidemiologyLung Diseases/*genetics/microbiologyMale*Microsatellite RepeatsMiddle AgedMycobacterium Infections, Atypical/epidemiology/*genetics/microbiologyMycobacterium avium ComplexMycobacterium avium-intracellulareInfection/epidemiology/*genetics/microbiologyPolymorphism, GeneticToll-Like Receptor 2/*genetics
Abstract
This study evaluated the association between the guanine-thymine (GT) repeat polymorphism in intron II of the Toll-like receptor 2 (TLR2) gene and lung disease caused by nontuberculous mycobacteria (NTM). Polymerase chain reaction and gene scans were used to determine the numbers of GT repeats for 193 patients with the nodular bronchiectatic form of NTM lung disease, including 110 patients with Mycobacterium avium-intracellulare (MAC) infection, 82 patients with Mycobacterium abscessus infection, and 1 patient with co-infection of both organisms. These values were compared with the results for 191 controls. Genotypes with shorter GT repeats were more common among patients with NTM lung disease (50.8 vs 37.7%, p=0.01). In the subgroup analysis, genotypes that included S alleles were more common in the patients with MAC lung disease (53.6%, p=0.01, OR, 1.91; 95% CI, 1.16, 3.16) than in healthy controls, whereas this difference was not statistically significant in patients with M. abscessus lung disease (47.6%, p=0.13). In conclusion, these results suggest that the GT repeat microsatellite polymorphisms in intron II of the human TLR2 gene contribute to the development of NTM lung disease, especially MAC lung disease, in a Korean population.
ISSN
0198-8859 (Print)
Language
English
URI
https://hdl.handle.net/10371/62221
DOI
https://doi.org/10.1016/j.humimm.2008.06.003
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College of Medicine/School of Medicine (의과대학/대학원)Internal Medicine (내과학전공)Journal Papers (저널논문_내과학전공)
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