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GABAergic amd serotonergic modulation of calcium currents in rat trigeminal motoneurons

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dc.contributor.authorPark, Kyungpyo-
dc.contributor.authorOh, Seog Bae-
dc.contributor.authorPiao, Zheng Gen-
dc.contributor.authorShin, Sang Sup-
dc.contributor.authorRen, Dong Jun-
dc.contributor.authorKim, Joong Soo-
dc.date.accessioned2010-03-31T07:15:23Z-
dc.date.available2010-03-31T07:15:23Z-
dc.date.issued2003-09-
dc.identifier.citationBIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 309 (2003), 58-65.en
dc.identifier.issn0006-291X-
dc.identifier.urihttps://hdl.handle.net/10371/62230-
dc.description.abstractWe investigated the effects of a GABAB agonist baclofen, and serotonin, on the high voltage-activated Ca channel (HVACC) currents in trigeminal motoneurons. Immunohistochemical and reverse transcription-polymerization chain reaction (RT-PCR) studies demonstrated the expression of α1C, α1B, α1A, and α1E subunits in the trigeminal motoneurons, which form L-, N-, P/Q-, and R-type Ca channels, respectively. By use of specific Ca blockers, it was found that N-type (38%), P/Q-type (27%), L-type (16 %), and R-type Ca currents (19%) contribute to HVACC IBa. Baclofen inhibited HVACC IBa in the majority of trigeminal motoneurons tested (n=15 outof 16), whereas serotonin only did in a small population (n=5 outof 18). The IBa inhibition by baclofen and serotonin was associated with slowing of activation kinetics, relieved by strong prepulse, and prevented by N-ethylmaleimide (NEM), indicative of mediation of Gi/Go. These data provide evidence that GABAergic and serotonergic inputs to trigeminal motoneurons regulate neuronal activities through the inhibition of HVACC currents.en
dc.description.sponsorshipThis work waas supported by Grant-in-Aid for scientific research from the Ministry of Health and Welfare, Republic of Korea, 00-PJ1-PG1-CH11-0004.en
dc.language.isoenen
dc.publisherElsevieren
dc.subjecttrigeminal motoneuronsen
dc.subjecthigh voltage-activated calcium channelsen
dc.subjectreverse transcription-polymerization chain reactionen
dc.subjectserotoninen
dc.subjectGABAen
dc.titleGABAergic amd serotonergic modulation of calcium currents in rat trigeminal motoneuronsen
dc.typeArticleen
dc.contributor.AlternativeAuthor박경표-
dc.contributor.AlternativeAuthor오석배-
dc.contributor.AlternativeAuthor신상섭-
dc.contributor.AlternativeAuthor김종수-
dc.identifier.doi10.1016/S0006-291X(03)01527-4-
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