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GABAergic amd serotonergic modulation of calcium currents in rat trigeminal motoneurons
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Park, Kyungpyo | - |
dc.contributor.author | Oh, Seog Bae | - |
dc.contributor.author | Piao, Zheng Gen | - |
dc.contributor.author | Shin, Sang Sup | - |
dc.contributor.author | Ren, Dong Jun | - |
dc.contributor.author | Kim, Joong Soo | - |
dc.date.accessioned | 2010-03-31T07:15:23Z | - |
dc.date.available | 2010-03-31T07:15:23Z | - |
dc.date.issued | 2003-09 | - |
dc.identifier.citation | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 309 (2003), 58-65. | en |
dc.identifier.issn | 0006-291X | - |
dc.identifier.uri | https://hdl.handle.net/10371/62230 | - |
dc.description.abstract | We investigated the effects of a GABAB agonist baclofen, and serotonin, on the high voltage-activated Ca channel (HVACC) currents in trigeminal motoneurons. Immunohistochemical and reverse transcription-polymerization chain reaction (RT-PCR) studies demonstrated the expression of α1C, α1B, α1A, and α1E subunits in the trigeminal motoneurons, which form L-, N-, P/Q-, and R-type Ca channels, respectively. By use of specific Ca blockers, it was found that N-type (38%), P/Q-type (27%), L-type (16 %), and R-type Ca currents (19%) contribute to HVACC IBa. Baclofen inhibited HVACC IBa in the majority of trigeminal motoneurons tested (n=15 outof 16), whereas serotonin only did in a small population (n=5 outof 18). The IBa inhibition by baclofen and serotonin was associated with slowing of activation kinetics, relieved by strong prepulse, and prevented by N-ethylmaleimide (NEM), indicative of mediation of Gi/Go. These data provide evidence that GABAergic and serotonergic inputs to trigeminal motoneurons regulate neuronal activities through the inhibition of HVACC currents. | en |
dc.description.sponsorship | This work waas supported by Grant-in-Aid for scientific research from the Ministry of Health and Welfare, Republic of Korea, 00-PJ1-PG1-CH11-0004. | en |
dc.language.iso | en | en |
dc.publisher | Elsevier | en |
dc.subject | trigeminal motoneurons | en |
dc.subject | high voltage-activated calcium channels | en |
dc.subject | reverse transcription-polymerization chain reaction | en |
dc.subject | serotonin | en |
dc.subject | GABA | en |
dc.title | GABAergic amd serotonergic modulation of calcium currents in rat trigeminal motoneurons | en |
dc.type | Article | en |
dc.contributor.AlternativeAuthor | 박경표 | - |
dc.contributor.AlternativeAuthor | 오석배 | - |
dc.contributor.AlternativeAuthor | 신상섭 | - |
dc.contributor.AlternativeAuthor | 김종수 | - |
dc.identifier.doi | 10.1016/S0006-291X(03)01527-4 | - |
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