Risk factors for bacterial pneumonia after cytotoxic chemotherapy in advanced lung cancer patients

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Lee, Jeong-Ok; Kim, Dae-Young; Lim, Joo Han; Seo, Myung-Deock; Yi, Hyeon Gyu; Kim, Yu Jung; Lee, Se-Hoon; Kim, Dong-Wan; Yang, Seok-Chul; Kim, Young Whan; Heo, Dae Seog

Issue Date
Elsevier BV
Lung Cancer, Vol.62 No.3, pp.381-384
The purpose of this study was to demonstrate the prevalence of and risk factors for pneumonia after cytotoxic chemotherapy in advanced lung cancer patients. We retrospectivety reviewed 193 out of 215 advanced tung cancer patients who were consecutively treated with cytotoxic chemotherapy at Seoul National University Hospital in 2005. The mean age was 61 years (range, 31-85 years). A total of 41 patients (21%) had Eastern cooperative oncology group (ECOG) performance status 2-3. Among 135 patients with pulmonary function test (PFT), 34% (n =46) of patients demonstrated an obstructive pattern of lung function. Pneumonia occurred in a total of 10 patients (5%). Occurrence rate was significantly higher in older patients (>70 years) than in younger ones (13% vs. 4%, p = 0.05), higher in patients with ECOG 2-3 compared with those with ECOG 0-1 (15% vs. 3%, p < 0.01), and higher in patients with an obstructive pattern of lung function compared with those without (11% vs. 1%, p = 0.02). Pneumonia occurrence rate in patients with all three risk factors was 25%. Six out of 10 pneumonia patients required hospitatization, and one patient died from respiratory failure. We identified this high-risk group as a candidate for antibacterial prophylaxis after cytotoxic chemotherapy in advanced lung cancer patients. (C) 2008 Elsevier Ireland Ltd. All rights reserved.
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College of Medicine/School of Medicine (의과대학/대학원)Dept. of Medicine (의학과)Journal Papers (저널논문_의학과)
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