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Palliative chemotherapy for patients with recurrent hepatocellular carcinoma after liver transplantation

Cited 30 time in Web of Science Cited 29 time in Scopus
Authors
Lee, Jeong-Ok; Kim, Dae-Young; Lim, Joo Han; Seo, Myung-Deok; Yi, Hyeon Gyu; Oh, Do-Youn; Im, Seock-Ah; Kim, Tae-You; Bang, Yung-Jue
Issue Date
2009-05
Publisher
Blackwell Publishing
Citation
Journal of Gastroenterology and Hepatology, Vol.24 No.5, pp.800-805
Keywords
chemotherapyhepatocellular carcinomaliver transplantationrecurrence
Abstract
The majority of patients with post-transplantation recurrence of hepatocellular carcinoma (HCC) have extrahepatic metastases and multifocal lesions. Therefore, they have few treatment options and may not be amenable for local therapy. The safety and efficacy of palliative chemotherapy in this population has not been reported. We retrospectively analyzed 24 patients who received palliative chemotherapy for recurrent HCC after liver transplantation between January 2000 and December 2006 at the Seoul National University Hospital. The mean age of patients was 55 years (range 42-70 years). The most commonly used chemotherapeutic regimens were 5-fluorouracil (5-FU)/cisplatin (n = 9), which was followed by capecitabine/cisplatin (n = 4), 5-FU/mitomycin (n = 3), 5-FU/oxaliplatin (n = 1), S-1 (n = 1), capecitabine (n = 1), gemcitabine/oxaliplatin (n = 1), gemcitabine/cisplatin (n = 1), 5-FU/interferon (n = 1) and sorafenib (n = 2). The Grade 3/4 hematological toxicity was neutropenia (29.1%), thrombocytopenia (20.9%) and anemia (20.9%). There were no cases of neutropenic fever or bleeding events. The Grade 3/4 non-hematological toxicity included elevation of liver transaminase (8.4%) and jaundice (16.7%). No patient showed an objective response and four patients (16.7%) demonstrated stable disease. The median time to progression was 7.0 weeks (95% CI 5.8-8.2) and the median overall survival was 16.6 weeks (95% CI 10.1-23.1). Palliative chemotherapy can be delivered to patients with recurrent HCC after liver transplantation with tolerable toxicity. However, the efficacy to date is not satisfactory. Therefore, more effective systemic chemotherapy is needed for this group of patients.
ISSN
0815-9319
Language
English
URI
http://hdl.handle.net/10371/62236
DOI
https://doi.org/10.1111/j.1440-1746.2008.05672.x
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College of Medicine/School of Medicine (의과대학/대학원)Internal Medicine (내과학전공)Journal Papers (저널논문_내과학전공)
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