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Expression of matrix metalloproteinase-2 and -9 in oral squamous cell carcinomas with regard to the metastatic potential

Cited 107 time in Web of Science Cited 108 time in Scopus
Authors
Hong, Sam-Pyo; Hong, Seong-Doo; Lee, Jae-Il; Lim, Chang-Yun
Issue Date
2000-03
Publisher
Pergamon
Citation
Oral Oncology, 2000;36:207-213.
Keywords
gelatin zymographyimmunohistochemistrymetastasisMMP-2MMP-9squamous cell carcinoma
Abstract
In order to evaluate the significance of matrix metalloproteinases (MMPs) in predicting the metastatic potential of oral squamous cell carcinomas (SCCs), we compared MMP-2 and -9 expression in 19 metastasizing oral SCCs with that in 25 non-metastasizing cases by immunohistochemistry and gelatin zymography. Immunohistochemistry showed that increased MMP-2 expression was not significantly related to metastasis; increased MMP-9 expression found in oral SCCs was, however, statistically significant (oral SCCs with metastasis, 73.7%; those without metastasis, 36.0%; P<0.05). Gelatin zymography revealed no significant difference in the activated form of MMP-2 between metastasizing and non-metastasizing oral SCCs. In metastasizing SCCs, on the other hand, increases in the activated form of MMP-9 were significant. These results suggest that oral SCCs express MMP-2 and -9, and that MMP-9 may play a more important role than MMP-2 in the metastasis of oral SCCs to adjacent tissue. An analysis of MMP-9 expression may be useful for predicting the metastatic potential of oral SCCs.
ISSN
1368-8375
Language
English
URI
http://hdl.handle.net/10371/62244
DOI
https://doi.org/10.1016/S1368-8375(99)00088-3
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College of Dentistry/School of Dentistry (치과대학/치의학대학원)Dept. of Dentistry (치의학과)Journal Papers (저널논문_치의학과)
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