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A newly identified member of the tumor necrosis factor receptor superfamily with a wide tissue distribution and involvement in lymphocyte activation
DC Field | Value | Language |
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dc.contributor.author | Kwon, Byoung S. | - |
dc.contributor.author | Tan, Kong B. | - |
dc.contributor.author | Ni, Jian | - |
dc.contributor.author | Oh, Kwi-Ok | - |
dc.contributor.author | Lee, Zang H | - |
dc.contributor.author | Ki, Kack K. | - |
dc.contributor.author | Kim, Young-J. | - |
dc.contributor.author | Wang, Sa | - |
dc.contributor.author | Gentz, Reiner | - |
dc.contributor.author | Yu, Guo-Liang | - |
dc.contributor.author | Harrop, Jeremy | - |
dc.contributor.author | Lyn, Sally D. | - |
dc.contributor.author | ol Silverman, Car | - |
dc.contributor.author | Porter, Terence G. | - |
dc.contributor.author | Truneh, Alem | - |
dc.contributor.author | Young, Peter R. | - |
dc.date.accessioned | 2010-04-01T04:36:33Z | - |
dc.date.available | 2010-04-01T04:36:33Z | - |
dc.date.issued | 1997-05-30 | - |
dc.identifier.citation | The Journal of Biological Chemistry, 272, 14272-14276. (1997) | en |
dc.identifier.issn | 0021-9258 | - |
dc.identifier.uri | https://hdl.handle.net/10371/62306 | - |
dc.description.abstract | The tumor necrosis factor receptor (TNFR) superfamily consists of approximately 10 characterized members of human proteins. We have identified a new member of the TNFR superfamily, TR2, from a search of an expressed sequence tag data base. cDNA cloning and Northern blot hybridization demonstrated multiple mRNA species, of which a 1.7-kilobase form was most abundant. However, TR2 is encoded by a single gene which, maps to chromosome 1p36.22–36.3, in the same region as several other members of the TNFR superfamily. The most abundant TR2 open reading frame encodes a 283-amino acid single transmembrane protein with a 36-residue signal sequence, two perfect and two imperfect TNFR-like cysteine-rich domains, and a short cytoplasmic tail with some similarity to 4–1BB and CD40. TR2 mRNA is expressed in multiple human tissues and cell lines and shows a constitutive and relatively high expression in peripheral blood T cells, B cells, and monocytes. A TR2-Fc fusion protein inhibited a mixed lymphocyte reaction-mediated proliferation suggesting that the receptor and/or its ligand play a role in T cell stimulation. | en |
dc.language.iso | en | en |
dc.publisher | American Society for Biochemistry and Molecular Biology | en |
dc.title | A newly identified member of the tumor necrosis factor receptor superfamily with a wide tissue distribution and involvement in lymphocyte activation | en |
dc.type | Article | en |
dc.identifier.doi | 10.1074/jbc.272.22.14272 | - |
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