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A newly identified member of the tumor necrosis factor receptor superfamily with a wide tissue distribution and involvement in lymphocyte activation

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dc.contributor.authorKwon, Byoung S.-
dc.contributor.authorTan, Kong B.-
dc.contributor.authorNi, Jian-
dc.contributor.authorOh, Kwi-Ok-
dc.contributor.authorLee, Zang H-
dc.contributor.authorKi, Kack K.-
dc.contributor.authorKim, Young-J.-
dc.contributor.authorWang, Sa-
dc.contributor.authorGentz, Reiner-
dc.contributor.authorYu, Guo-Liang-
dc.contributor.authorHarrop, Jeremy-
dc.contributor.authorLyn, Sally D.-
dc.contributor.authorol Silverman, Car-
dc.contributor.authorPorter, Terence G.-
dc.contributor.authorTruneh, Alem-
dc.contributor.authorYoung, Peter R.-
dc.date.accessioned2010-04-01T04:36:33Z-
dc.date.available2010-04-01T04:36:33Z-
dc.date.issued1997-05-30-
dc.identifier.citationThe Journal of Biological Chemistry, 272, 14272-14276. (1997)en
dc.identifier.issn0021-9258-
dc.identifier.urihttps://hdl.handle.net/10371/62306-
dc.description.abstractThe tumor necrosis factor receptor (TNFR) superfamily consists of approximately 10 characterized members of human proteins. We have identified a new member of the TNFR superfamily, TR2, from a search of an expressed sequence tag data base. cDNA cloning and Northern blot hybridization demonstrated multiple mRNA species, of which a 1.7-kilobase form was most abundant. However, TR2 is encoded by a single gene which, maps to chromosome 1p36.22–36.3, in the same region as several other members of the TNFR superfamily. The most abundant TR2 open reading frame encodes a 283-amino acid single transmembrane protein with a 36-residue signal sequence, two perfect and two imperfect TNFR-like cysteine-rich domains, and a short cytoplasmic tail with some similarity to 4–1BB and CD40. TR2 mRNA is expressed in multiple human tissues and cell lines and shows a constitutive and relatively high expression in peripheral blood T cells, B cells, and monocytes. A TR2-Fc fusion protein inhibited a mixed lymphocyte reaction-mediated proliferation suggesting that the receptor and/or its ligand play a role in T cell stimulation.en
dc.language.isoenen
dc.publisherAmerican Society for Biochemistry and Molecular Biologyen
dc.titleA newly identified member of the tumor necrosis factor receptor superfamily with a wide tissue distribution and involvement in lymphocyte activationen
dc.typeArticleen
dc.identifier.doi10.1074/jbc.272.22.14272-
Appears in Collections:
College of Dentistry/School of Dentistry (치과대학/치의학대학원)Dept. of Dentistry (치의학과)Journal Papers (저널논문_치의학과)
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