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Effect of matrix metalloproteinase-9 -1562C/T gene polymorphism on manifestations of pulmonary tuberculosis
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, Seung Heon | - |
dc.contributor.author | Han, Sung Koo | - |
dc.contributor.author | Shim, Young-Soo | - |
dc.contributor.author | Yim, Jae-Joon | - |
dc.date.accessioned | 2010-04-01T05:15:42Z | - |
dc.date.available | 2010-04-01T05:15:42Z | - |
dc.date.issued | 2008-10-07 | - |
dc.identifier.citation | Tuberculosis (Edinb). 2009 ;89(1):68-70. | en |
dc.identifier.issn | 1873-281X (Electronic) | - |
dc.identifier.uri | https://hdl.handle.net/10371/62314 | - |
dc.description.abstract | Increased levels of matrix metalloproteinase-9 (MMP-9) in patients with tuberculous meningitis, tuberculous pleuritis, and advanced pulmonary tuberculosis (TB) suggest a pivotal role for MMP-9 in the development of pulmonary TB and its clinical manifestations. The present study was performed to evaluate the role of the -1562C/T single nucleotide polymorphism (SNP) in the promoter region of the human MMP-9 gene in development of pulmonary TB and its radiographic characteristics. A case-control study was performed with a study population of 205 patients with pulmonary TB and 223 healthy controls. Differences were explored in the allele and genotype distributions of the -1562C/T polymorphism between patients with pulmonary TB and healthy controls, between patients with single- and multi-lobe involvement, and between patients with and without cavities. The -1562C/C genotype was more common in patients with multi-lobe involvement than in those with single-lobe involvement (81.8 vs. 67.6%, P=0.03). However, there were no significant differences in the distribution between patients with pulmonary TB and healthy controls (P=0.40) or between patients with and without cavities (P=0.18). These results suggest that the -1562C/C genotype is associated with the intrapulmonary spread of TB rather than its development. | en |
dc.language.iso | en | en |
dc.publisher | Elsevier | en |
dc.subject | Adolescent | en |
dc.subject | Adult | en |
dc.subject | Aged | en |
dc.subject | Aged, 80 and over | en |
dc.subject | Case-Control Studies | en |
dc.subject | Female | en |
dc.subject | Genetic Predisposition to Disease | en |
dc.subject | Genotype | en |
dc.subject | Humans | en |
dc.subject | Logistic Models | en |
dc.subject | Lung/*radiography | en |
dc.subject | Male | en |
dc.subject | Matrix Metalloproteinase 9/*genetics | en |
dc.subject | Middle Aged | en |
dc.subject | Odds Ratio | en |
dc.subject | Tuberculosis, Pulmonary/*enzymology/genetics/*radiography | en |
dc.subject | Young Adult | en |
dc.subject | Polymorphism, Single Nucleotide | - |
dc.title | Effect of matrix metalloproteinase-9 -1562C/T gene polymorphism on manifestations of pulmonary tuberculosis | en |
dc.type | Article | en |
dc.contributor.AlternativeAuthor | 이승현 | - |
dc.contributor.AlternativeAuthor | 한성구 | - |
dc.contributor.AlternativeAuthor | 심영수 | - |
dc.contributor.AlternativeAuthor | 임재준 | - |
dc.identifier.doi | 10.1016/j.tube.2008.08.001 | - |
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