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Rapid induction of malignant tumor in Sprague-Dawley rats by injection of RME-ras cells

Cited 12 time in Web of Science Cited 12 time in Scopus
Authors
Park, Joo-Cheol; Kim, Soo-A; Kim, Hyun-Woo; Kim, Do-Kyung; Kim, Su-Gwan; Kang, Dong-Wan; Kim, Si-Wouk; Ahn, Sang-Gun; Yoon, Jung-Hoon
Issue Date
2006-04
Publisher
Elsevier
Citation
CANCER LETTERS, 235 (2006), 53-59.
Keywords
RK3Ek-rasTumor modelSprague–Dawley rat
Abstract
Several tumor animal models have been provided as a tool for developing cancer therapy. Here, we developed rapid, easy-to use, and cost-effective new rat animal model for invasion and metastasis of cancer using genetically k-ras-induced rat kidney cells (RK3E-ras). We observed tumor as early as 3 days after injection of RK3E-ras cells in subcutaneous of Sprague–Dawley rats. Tumor size and volume were increased exponentially for 2 weeks. The tail vein injected rats obtained the lethal infiltration in the lung within 2 weeks. This tumor animal model has great potential for studying cancer processes and short-term screening of variable cancer therapy strategy.
ISSN
0304-3835
Language
English
URI
http://hdl.handle.net/10371/62315
DOI
https://doi.org/10.1016/j.canlet.2005.04.003
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College of Dentistry/School of Dentistry (치과대학/치의학대학원)Dept. of Dentistry (치의학과)Journal Papers (저널논문_치의학과)
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