S-Space College of Dentistry/School of Dentistry (치과대학/치의학대학원) Dept. of Dentistry (치의학과) Journal Papers (저널논문_치의학과)
Rapid induction of malignant tumor in Sprague-Dawley rats by injection of RME-ras cells
- Park, Joo-Cheol; Kim, Soo-A; Kim, Hyun-Woo; Kim, Do-Kyung; Kim, Su-Gwan; Kang, Dong-Wan; Kim, Si-Wouk; Ahn, Sang-Gun; Yoon, Jung-Hoon
- Issue Date
- CANCER LETTERS, 235 (2006), 53-59.
- Several tumor animal models have been provided as a tool for developing cancer therapy. Here, we developed rapid, easy-to use, and cost-effective new rat animal model for invasion and metastasis of cancer using genetically k-ras-induced rat kidney cells (RK3E-ras). We observed tumor as early as 3 days after injection of RK3E-ras cells in subcutaneous of Sprague–Dawley rats. Tumor size and volume were increased exponentially for 2 weeks. The tail vein injected rats obtained the lethal infiltration in the lung within 2 weeks. This tumor animal model has great potential for studying cancer processes and short-term screening of variable cancer therapy strategy.
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