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College of Dentistry/School of Dentistry (치과대학/치의학대학원)
Dept. of Dentistry (치의학과)
Journal Papers (저널논문_치의학과)
Rapid induction of malignant tumor in Sprague-Dawley rats by injection of RME-ras cells
- Authors
- Park, Joo-Cheol ; Kim, Soo-A ; Kim, Hyun-Woo ; Kim, Do-Kyung ; Kim, Su-Gwan ; Kang, Dong-Wan ; Kim, Si-Wouk ; Ahn, Sang-Gun ; Yoon, Jung-Hoon
- Issue Date
- 2006-04
- Publisher
- Elsevier
- Citation
- CANCER LETTERS, 235 (2006), 53-59.
- Keywords
- RK3E ; k-ras ; Tumor model ; Sprague–Dawley rat
- Abstract
- Several tumor animal models have been provided as a tool for developing cancer therapy. Here, we developed rapid, easy-to use, and cost-effective new rat animal model for invasion and metastasis of cancer using genetically k-ras-induced rat kidney cells (RK3E-ras). We observed tumor as early as 3 days after injection of RK3E-ras cells in subcutaneous of Sprague–Dawley rats. Tumor size and volume were increased exponentially for 2 weeks. The tail vein injected rats obtained the lethal infiltration in the lung within 2 weeks. This tumor animal model has great potential for studying cancer processes and short-term screening of variable cancer therapy strategy.
- ISSN
- 0304-3835
- Language
- English
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