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Genetic variations in soluble epoxide hydrolase and graft function in kidney transplantation

Cited 19 time in Web of Science Cited 19 time in Scopus
Authors
Lee, S. H.; Lee, J.; Cha, R.; Park, M. H.; Ha, J. W.; Kim, S.; Kim, Y. S.
Issue Date
2008-07-01
Publisher
Elsevier
Citation
Transplant Proc. 2008 ;40(5):1353-6.
Keywords
3' Untranslated Regions/geneticsAdultArachidonic Acids/metabolismEpoxide Hydrolases/*geneticsExonsFollow-Up Studies*Genetic VariationHumansKidney Transplantation/*physiologyMiddle AgedTreatment Outcome
Abstract
BACKGROUND: Epoxyeicosatrienoic acids (EETs) are endothelium-derived hyperpolarizing factors that contribute renal protective actions. The aim of this study was to identify the association between genetic variations in soluble epoxide hydrolase (EPHX2, EET-metabolizing enzyme) and kidney allograft dysfunction. MATERIALS AND METHODS: Data from 204 kidney transplant donor-recipient pairs were examined for polymorphisms of exon 8 (R287Q, rs751141 G/A) and 3' untranslated region (3' UTR, rs1042032 A/G) of the EPHX2 gene and correlated with clinical data. RESULTS: The mean duration of follow-up for recipients was 58 +/- 45.3 months who were 39 +/- 11.8 years old at the time of operation and displayed estimated glomerular filtration rate (eGFR) of 68 +/- 16.5 mL/min/1.73 m2 at 1 month after transplantation. AA, AG, and GG genotype frequencies in 3' UTR were 28%, 55%, and 16%, respectively. Twenty-one recipients experienced allograft dysfunction with eGFR <30 mL/min/1.73 m2; 10 had AA genotype of rs1042032 polymorphism (chi-square test; A/A vs A/G+G/G; P = .04). Recipients without rs1042032 polymorphism variant allele showed a significant risk for allograft dysfunction (A/A vs A/G+G/G; P = .04; odds ratio, 2.65; 95% confidence interval [CI], 1.03-6.81). Multivariate analysis of the characteristics of patients using a Cox proportional hazard model showed that the AA genotype of rs1042032 polymorphism was predictive of allograft dysfunction (Hazard Ratio = 3.26; P = .04; 95% CI, 1.08-9.59). CONCLUSION: The present study suggested that the presence of the rs1042032 variant allele in EPHX2 was associated with a protective role for allograft function.
ISSN
0041-1345 (Print)
Language
English
URI
https://hdl.handle.net/10371/62319
DOI
https://doi.org/10.1016/j.transproceed.2008.03.137
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College of Medicine/School of Medicine (의과대학/대학원)Internal Medicine (내과학전공)Journal Papers (저널논문_내과학전공)
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