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Enhanced anti-tumor effect of combination therapy with gemcitabine and apigenin in pancreatic cancer
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, Sang Hyub | - |
dc.contributor.author | Ryu, Ji Kon | - |
dc.contributor.author | Lee, Kyeung-Yeup | - |
dc.contributor.author | Woo, Sang Myung | - |
dc.contributor.author | Park, Joo Kyung | - |
dc.contributor.author | Yoo, Ji Won | - |
dc.contributor.author | Kim, Yong-Tae | - |
dc.contributor.author | Yoon, Yong Bum | - |
dc.date.accessioned | 2010-04-01T05:35:55Z | - |
dc.date.available | 2010-04-01T05:35:55Z | - |
dc.date.issued | 2007-10-31 | - |
dc.identifier.citation | Cancer Lett. 2008 ;259(1):39-49. | en |
dc.identifier.issn | 0304-3835 (Print) | - |
dc.identifier.uri | https://hdl.handle.net/10371/62320 | - |
dc.description.abstract | Apigenin is a dietary flavonoid possessing therapeutic potential against cancers. This study was designed to investigate whether combination therapy with gemcitabine and apigenin enhanced anti-tumor efficacy in pancreatic cancer. In vitro, the combination treatment resulted in more growth inhibition and apoptosis through the down-regulation of NF-kappa B activity with suppression of Akt activation in pancreatic cancer cell lines (MiaPaca-2, AsPC-1). In vivo, the combination therapy augmented tumor growth inhibition through the down-regulation of NF-kappa B activity with the suppression of Akt in tumor tissue. The combination of gemcitabine and apigenin enhanced anti-tumor efficacy through Akt and NF-kappa B activity suppression and apoptosis induction. | en |
dc.language.iso | en | en |
dc.publisher | Elsevier | en |
dc.subject | Animals | en |
dc.subject | Antimetabolites, Antineoplastic/administration & dosage | en |
dc.subject | Antineoplastic Combined Chemotherapy Protocols/*pharmacology/therapeutic use | en |
dc.subject | Apigenin/administration & dosage | en |
dc.subject | Apoptosis/drug effects | en |
dc.subject | Cell Line, Tumor | en |
dc.subject | Cell Proliferation/drug effects | en |
dc.subject | Deoxycytidine/administration & dosage/analogs & derivatives | en |
dc.subject | Dose-Response Relationship, Drug | en |
dc.subject | Down-Regulation | en |
dc.subject | Drug Synergism | en |
dc.subject | Humans | en |
dc.subject | Mice | en |
dc.subject | NF-kappa B/metabolism | en |
dc.subject | Pancreatic Neoplasms/*drug therapy/metabolism/pathology | en |
dc.subject | Proto-Oncogene Proteins c-akt/metabolism | en |
dc.subject | Xenograft Model Antitumor Assays | en |
dc.subject | bcl-2-Associated X Protein/metabolism | en |
dc.title | Enhanced anti-tumor effect of combination therapy with gemcitabine and apigenin in pancreatic cancer | en |
dc.type | Article | en |
dc.contributor.AlternativeAuthor | 이상협 | - |
dc.contributor.AlternativeAuthor | 류지곤 | - |
dc.contributor.AlternativeAuthor | 이경엽 | - |
dc.contributor.AlternativeAuthor | 우상명 | - |
dc.contributor.AlternativeAuthor | 박주경 | - |
dc.contributor.AlternativeAuthor | 우지원 | - |
dc.contributor.AlternativeAuthor | 김용태 | - |
dc.contributor.AlternativeAuthor | 윤용범 | - |
dc.identifier.doi | 10.1016/j.canlet.2007.09.015 | - |
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