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Matrix metalloproteinase-9 promoter polymorphisms in Korean patients with systemic lupus erythematosus
DC Field | Value | Language |
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dc.contributor.author | Lee, Yun Jong | - |
dc.contributor.author | Woo, Mijung | - |
dc.contributor.author | Nam, Jung-Hyun | - |
dc.contributor.author | Baek, Jinah | - |
dc.contributor.author | Im, Churl Hyun | - |
dc.contributor.author | Lee, Eun Young | - |
dc.contributor.author | Lee, Eun Bong | - |
dc.contributor.author | Park, Kyung Sook | - |
dc.contributor.author | Song, Yeong Wook | - |
dc.date.accessioned | 2010-04-01T06:03:16Z | - |
dc.date.available | 2010-04-01T06:03:16Z | - |
dc.date.issued | 2008-06-24 | - |
dc.identifier.citation | Hum Immunol. 2008 ;69(6):374-9. | en |
dc.identifier.issn | 0198-8859 (Print) | - |
dc.identifier.uri | https://hdl.handle.net/10371/62323 | - |
dc.description.abstract | To investigate the association between functional promoter polymorphisms of matrix metalloproteinase-9 (MMP-9) and systemic lupus erythematosus (SLE), we analyzed MMP-9 promoter -1562 C>T and MMP-9 -90 (CA)(n) repeat polymorphisms in 135 Korean SLE patients (mean age, 34.7 years; 124 female and 11 male) and in 135 gender- and age-matched healthy controls (mean age, 35.4 years). Clinical and laboratory findings were collected during the follow-up period (mean, 63.5 months; range, 3-252 months), and Systemic Lupus International Collaborating Clinics/American College of Rheumatology (SLICC/ACR) Damage Indexes were calculated. The levels of total MMP-9 were measured in sera of SLE patients and controls by enzyme-linked immunoabsorbent assay. The serum levels of MMP-9 in SLE patients were significantly lower than those of controls (mean +/- standard error of the mean, 1421.6+/-177.4 vs 3731.4+/-441.4 ng/ml, p=1.2 x 10(-5) by t test). Both functional polymorphisms were under the Hardy-Weinberg equilibrium state except (CA)(n) repeat polymorphisms in SLE patients (p=2.6 x 10(-5) by chi(2) goodness-of-fit test). The distribution of the MMP-9 promoter polymorphisms or haplotypes was not significantly different in SLE patients and controls. However the frequency of alleles with low numbers of CA repeats (n<21, 11.9% vs 7.0%, p=0.06 by the chi(2) test; odds ratio=1.78, 95% confidence interval=0.99-3.20) and the prevalence of low CA repeats homozygote tended to be higher in patients than in controls (5.2% vs 0.7%, p=0.07 by logistic regression, odds ratio=7.29, 95% confidence interval=0.88-60.10) in the recessive model. No relationship was found between MMP-9 polymorphisms and clinical features or damage as indicated by SLICC/ACR Damage Index in the study subjects. These results suggest that genetic polymorphisms of the MMP-9 promoter regions are not associated with the development of SLE in Korea. | en |
dc.description.sponsorship | This work was supported by a grant from the Korean ministry of Science & Technology through the National Research Laboratory Program for Rheumatic Disease. | en |
dc.language.iso | en | en |
dc.publisher | Elsevier | en |
dc.subject | Adult | en |
dc.subject | Aged | en |
dc.subject | Female | en |
dc.subject | Gene Frequency | en |
dc.subject | Genotype | en |
dc.subject | Humans | en |
dc.subject | Korea | en |
dc.subject | Lupus Erythematosus, Systemic/blood/*genetics | en |
dc.subject | Male | en |
dc.subject | Matrix Metalloproteinase 9/*genetics | en |
dc.subject | Middle Aged | en |
dc.subject | Polymorphism, Genetic | en |
dc.subject | Promoter Regions, Genetic | - |
dc.title | Matrix metalloproteinase-9 promoter polymorphisms in Korean patients with systemic lupus erythematosus | en |
dc.type | Article | en |
dc.contributor.AlternativeAuthor | 이윤종 | - |
dc.contributor.AlternativeAuthor | 우미정 | - |
dc.contributor.AlternativeAuthor | 남정현 | - |
dc.contributor.AlternativeAuthor | 백진아 | - |
dc.contributor.AlternativeAuthor | 임철현 | - |
dc.contributor.AlternativeAuthor | 이은영 | - |
dc.contributor.AlternativeAuthor | 이은봉 | - |
dc.contributor.AlternativeAuthor | 박경숙 | - |
dc.contributor.AlternativeAuthor | 송영욱 | - |
dc.identifier.doi | 10.1016/j.humimm.2008.03.005 | - |
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