Neutrophil CD64 expression is associated with severity and prognosis of disseminated intravascular coagulation

Cited 30 time in Web of Science Cited 29 time in Scopus

Song, Sang Hoon; Kim, Hyun Kyung; Park, Myoung Hee; Cho, Han-Ik

Issue Date
Thromb Res. 2008;121(4):499-507. Epub 2007 Jun 26.
AdultAgedAntigens, CD/bloodAntigens, Differentiation, Myelomonocytic/bloodDisseminated Intravascular Coagulation/*blood/mortalityFemaleHumansLeukocyte Elastase/bloodMaleMiddle AgedNeutrophils/*chemistryPrognosisReceptors, Cell Surface/bloodReceptors, IgG/*blood
INTRODUCTION: Although neutrophil can be activated by microcirculatory disturbances in DIC, its relation with the severity and prognosis of DIC has not been elucidated. We investigated the relationship between neutrophil activation and DIC severity and determined the prognostic value of neutrophil activation markers in patients with DIC. MATERIALS AND METHODS: We measured two neutrophil activation markers, neutrophil CD64 expression and plasma neutrophil elastase, in 94 patients with suspected DIC and 55 healthy controls. Neutrophil CD64 expression and plasma neutrophil elastase were measured using CD64 quantitation kit, and PMN Elastase enzyme immunoassay kit. RESULTS: Neutrophil CD64 expression and plasma neutrophil elastase level were significantly increased in patients with overt and non-overt DIC compared to normal controls (P<0.001, each). Neutrophil CD64 expression showed a significant linear trend of increase with increasing DIC score (P<0.001). In DIC patients, significant differences were observed between those with and without infection both in overt (P=0.003) and non-overt DIC (P=0.004). Neutrophil CD64 expression was significantly increased in 28-day non-survival group compared to survival group in both overt (P<0.001) and non-overt DIC (P=0.032). The 28-day survival rate showed a stronger association with the neutrophil CD64 expression (P<0.001) than with DIC score (P=0.028) or plasma neutrophil elastase level (P=0.246). CONCLUSIONS: Neutrophil CD64 expression is significantly correlated with DIC severity and has a good predictive value for the 28-day mortality in patients suspected of having DIC. Neutrophil CD64 expression might be useful in monitoring the disease course and in predicting mortality in DIC patients.
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College of Medicine/School of Medicine (의과대학/대학원)Laboratory Medicine (검사의학전공)Journal Papers (저널논문_검사의학전공)
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