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The effects of probiotics on PPI-triple therapy for Helicobacter pylori eradication
DC Field | Value | Language |
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dc.contributor.author | Kim, Mi Na | - |
dc.contributor.author | Kim, Nayoung | - |
dc.contributor.author | Lee, Sang Hyup | - |
dc.contributor.author | Park, Young Soo | - |
dc.contributor.author | Hwang, Jin-Hyeok | - |
dc.contributor.author | Kim, Jin-Wook | - |
dc.contributor.author | Jeong, Sook-Hyang | - |
dc.contributor.author | Lee, Dong Ho | - |
dc.contributor.author | Kim, Joo Sung | - |
dc.contributor.author | Jung, Hyun Chae | - |
dc.contributor.author | Song, In Sung | - |
dc.date.accessioned | 2010-04-01T23:57:11Z | - |
dc.date.available | 2010-04-01T23:57:11Z | - |
dc.date.issued | 2008-07-31 | - |
dc.identifier.citation | Helicobacter. 2008 ;13(4):261-8. | en |
dc.identifier.issn | 1523-5378 (Electronic) | - |
dc.identifier.uri | https://hdl.handle.net/10371/62368 | - |
dc.description.abstract | BACKGROUND: This study was performed to evaluate whether the addition of probiotics to proton pump inhibitor (PPI)-based triple therapy increases the likelihood of successful Helicobacter pylori eradication. MATERIALS AND METHODS: Three hundred and forty-seven H. pylori-infected patients were randomized into a triple-plus-yogurt group (yogurt group, n = 168) or a triple-only group (control group, n = 179). Triple therapy consisted of PPI b.i.d., clarithromycin 500 mg b.i.d., and amoxicillin 1 g b.i.d. for 7 days. Yogurt group received triple therapy for 1 week and one bottle of Will yogurt per day for at 3 weeks, starting on the first day of triple therapy. Will yogurt (a Korean brand) contains Lactobacillus acidophilus HY2177, Lactobacillus casei HY2743, Bifidobacterium longum HY8001, and Streptococcus thermophilus B-1. (13)C-urea breath test was performed at least 4 weeks after completion of triple therapy. Eradication rates, compliances, and adverse events were compared. RESULTS: By intention-to treat analysis the H. pylori eradication rates in the yogurt group 79.2% (133 of 168) was similar to that in the control group 72.1% (129 of 179) (p = .124). However, by per-protocol (PP) analysis, the eradication rate in the yogurt group, 87.5% (133 of 152) was higher than that in the control group, 78.7% (129 of 164) (p = .037). Common adverse events were metallic taste (11.8%) and diarrhea (8.6%). The frequency of adverse effects in the yogurt group 41.1% (69/168) were higher than in the control group, 26.3% (47 of 179) (p = .003). However, most adverse events were mild to moderate in intensity, and the severities of adverse effects were similar in both groups (p = .401). CONCLUSIONS: The addition of Will yogurt to triple therapy did not reduce the side-effects of triple therapy. But it increased the H. pylori eradication rate by PP analysis, encouraging more research in this field. | en |
dc.description.sponsorship | This study was supported by the Korean Health 21 R&G Project, Ministry of Health and Welfare, Republic of Korea(no.A060266). | en |
dc.language.iso | en | en |
dc.publisher | Wiley-Blackwell | en |
dc.subject | Adolescent | en |
dc.subject | Adult | en |
dc.subject | Aged | en |
dc.subject | Aged, 80 and over | en |
dc.subject | Amoxicillin/administration & dosage/adverse effects | en |
dc.subject | Breath Tests | en |
dc.subject | Clarithromycin/administration & dosage/adverse effects | en |
dc.subject | Drug Therapy, Combination | en |
dc.subject | Female | en |
dc.subject | Helicobacter Infections/*drug therapy/microbiology | en |
dc.subject | Helicobacter pylori/*isolation & purification | en |
dc.subject | Humans | en |
dc.subject | Male | en |
dc.subject | Middle Aged | en |
dc.subject | Probiotics/*therapeutic use | en |
dc.subject | Prospective Studies | en |
dc.subject | Proton Pump Inhibitors/*administration & dosage/adverse effects | en |
dc.subject | Yogurt/*microbiology | en |
dc.title | The effects of probiotics on PPI-triple therapy for Helicobacter pylori eradication | en |
dc.type | Article | en |
dc.contributor.AlternativeAuthor | 김미나 | - |
dc.contributor.AlternativeAuthor | 김나영 | - |
dc.contributor.AlternativeAuthor | 이상협 | - |
dc.contributor.AlternativeAuthor | 박영수 | - |
dc.contributor.AlternativeAuthor | 황진혁 | - |
dc.contributor.AlternativeAuthor | 김진욱 | - |
dc.contributor.AlternativeAuthor | 정숙향 | - |
dc.contributor.AlternativeAuthor | 이동호 | - |
dc.contributor.AlternativeAuthor | 김주성 | - |
dc.contributor.AlternativeAuthor | 정현채 | - |
dc.contributor.AlternativeAuthor | 송인성 | - |
dc.identifier.doi | 10.1111/j.1523-5378.2008.00601.x | - |
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