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CD24 cross-linking induces apoptosis in, and inhibits migration of, MCF-7 breast cancer cells
DC Field | Value | Language |
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dc.contributor.author | Kim, Jong Bin | - |
dc.contributor.author | Ko, Eunyoung | - |
dc.contributor.author | Han, Wonshik | - |
dc.contributor.author | Lee, Jeong Eon | - |
dc.contributor.author | Lee, Kyung-Min | - |
dc.contributor.author | Shin, Incheol | - |
dc.contributor.author | Kim, Sangmin | - |
dc.contributor.author | Lee, Jong Won | - |
dc.contributor.author | Cho, Jihyoung | - |
dc.contributor.author | Bae, Ji-Yeon | - |
dc.contributor.author | Jee, Hyeon-Gun | - |
dc.contributor.author | Noh, Dong-Young | - |
dc.date.accessioned | 2010-04-05T03:58:42Z | - |
dc.date.available | 2010-04-05T03:58:42Z | - |
dc.date.issued | 2008-04-25 | - |
dc.identifier.citation | BMC Cancer 8:118-127 | en |
dc.identifier.issn | 1471-2407 (Electronic) | - |
dc.identifier.uri | https://hdl.handle.net/10371/62504 | - |
dc.description.abstract | BACKGROUND: The biological effects of CD24 (FL-80) cross-linking on breast cancer cells have not yet been established. We examined the impact of CD24 cross-linking on human breast cancer cell line MCF-7. METHODS: MCF-7 and MDA-MB-231 cells were treated with anti-rabbit polyclonal IgG or anti-human CD24 rabbit polyclonal antibodies to induce cross-linking, and then growth was studied. Changes in cell characteristics such as cell cycle modulation, cell death, survival in three-dimensional cultures, adhesion, and migration ability were assayed after CD24 cross-linking in MCF-7. RESULTS: Expression of CD24 was analyzed by flow cytometry in MDA-MB-231 and MCF-7 cells where 2% and 66% expression frequencies were observed, respectively. CD24 cross-linking resulted in time-dependent proliferation reduction in MCF-7 cells, but no reduction in MDA-MB-231 cells. MCF-7 cell survival was reduced by 15% in three-dimensional culture after CD24 cross-linking. Increased MCF-7 cell apoptosis was observed after CD24 cross-linking, but no cell cycle arrest was observed in that condition. The migration capacity of MCF-7 cells was diminished by 30% after CD24 cross-linking. CONCLUSION: Our results showed that CD24 cross-linking induced apoptosis and inhibited migration in MCF-7 breast cancer cells. We conclude that CD24 may be considered as a novel therapeutic target for breast cancer. | en |
dc.language.iso | en | en |
dc.publisher | BioMed Central | en |
dc.subject | Animals | en |
dc.subject | Antigens, CD24/*immunology | en |
dc.subject | Apoptosis/*immunology | en |
dc.subject | Breast Neoplasms/immunology/pathology/therapy | en |
dc.subject | Cell Line, Tumor | en |
dc.subject | Complement System Proteins/*immunology/metabolism | en |
dc.subject | Feedback, Biochemical | en |
dc.subject | Female | en |
dc.subject | Humans | en |
dc.subject | Immunoglobulin Fc Fragments/metabolism/therapeutic use | en |
dc.subject | Neoplasm Invasiveness | en |
dc.subject | Neoplasm Metastasis | en |
dc.subject | Rabbits | en |
dc.subject | Receptors, Fc/metabolism | en |
dc.subject | Signal Transduction | en |
dc.title | CD24 cross-linking induces apoptosis in, and inhibits migration of, MCF-7 breast cancer cells | en |
dc.type | Article | en |
dc.contributor.AlternativeAuthor | 김종빈 | - |
dc.contributor.AlternativeAuthor | 고은영 | - |
dc.contributor.AlternativeAuthor | 한원식 | - |
dc.contributor.AlternativeAuthor | 이정연 | - |
dc.contributor.AlternativeAuthor | 이경민 | - |
dc.contributor.AlternativeAuthor | 신인철 | - |
dc.contributor.AlternativeAuthor | 김상민 | - |
dc.contributor.AlternativeAuthor | 이종원 | - |
dc.contributor.AlternativeAuthor | 조지형 | - |
dc.contributor.AlternativeAuthor | 배지연 | - |
dc.contributor.AlternativeAuthor | 지현건 | - |
dc.contributor.AlternativeAuthor | 노동영 | - |
dc.identifier.doi | 10.1186/1471-2407-8-118 | - |
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