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Coding region polymorphisms in the CHFR mitotic stress checkpoint gene are associated with colorectal cancer risk

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dc.contributor.authorKang, Hio Chung-
dc.contributor.authorKim, Il-Jin-
dc.contributor.authorJang, Sang-Geun-
dc.contributor.authorHong, Seung-Hyun-
dc.contributor.authorHwang, Jung-Ah-
dc.contributor.authorShin, Hai-Rim-
dc.contributor.authorPark, Jae-Gahb-
dc.date.accessioned2010-04-05T08:15:37Z-
dc.date.available2010-04-05T08:15:37Z-
dc.date.issued2007-12-15-
dc.identifier.citationCancer Lett. 260 (2007) 170-179en
dc.identifier.issn0304-3835 (Print)-
dc.identifier.urihttp://hdl.handle.net/10371/62537-
dc.description.abstractCHFR was recently identified as an early mitotic checkpoint that delays transition to metaphase in response to mitotic stress. Although studies have shown that CHFR is relevant to tumorigenesis, no previous report has investigated whether polymorphisms in the CHFR gene are associated with the risk of cancer development. Here, we genotyped polymorphisms in the CHFR gene and analyzed the possible associations of single polymorphisms and haplotypes with the risk and clinicopathological characteristics of colorectal cancer. Six coding SNPs in the CHFR gene were genotyped in 462 colorectal cancer patients and 245 healthy normal controls, using either the TaqMan assay or direct sequencing. Our results revealed that the V539M polymorphism was significantly associated with a lower risk of colorectal cancer (P=0.03; OR, 0.533; 95% CI, 0.302-0.94), and significantly correlated with no distant metastasis (M0 stage), different TNM stage, and microsatellite instability (MSI) among the colorectal cancer patients. Among the five tested haplotypes, hap 10 (TGACTA) was significantly associated with a lower risk of colorectal cancer (P=0.017; OR, 0.496; 95% CI, 0.279-0.883), and colorectal cancer patients carrying this haplotype showed no distant metastasis, different TNM stage, and microsatellite instability at a significantly higher frequency. These results reveal for the first time that polymorphisms in the CHFR gene are associated with colorectal cancer susceptibility.en
dc.language.isoenen
dc.publisherElsevieren
dc.subjectCase-Control Studiesen
dc.subjectCell Cycle Proteins/*geneticsen
dc.subjectColorectal Neoplasms/*genetics/pathologyen
dc.subject*Gene Expression Regulation, Neoplasticen
dc.subjectGenetic Predisposition to Diseaseen
dc.subjectHaplotypesen
dc.subjectMicrosatellite Instabilityen
dc.subjectMitosis/*geneticsen
dc.subjectNeoplasm Metastasisen
dc.subjectNeoplasm Proteins/*geneticsen
dc.subjectNeoplasm Stagingen
dc.subjectOdds Ratioen
dc.subjectPhenotypeen
dc.subject*Polymorphism, Single Nucleotideen
dc.subjectRisk Assessmenten
dc.subjectRisk Factorsen
dc.titleCoding region polymorphisms in the CHFR mitotic stress checkpoint gene are associated with colorectal cancer risken
dc.typeArticleen
dc.contributor.AlternativeAuthor강효정-
dc.contributor.AlternativeAuthor김일진-
dc.contributor.AlternativeAuthor장상근-
dc.contributor.AlternativeAuthor홍승현-
dc.contributor.AlternativeAuthor황정아-
dc.contributor.AlternativeAuthor신해림-
dc.contributor.AlternativeAuthor박재갑-
dc.identifier.doi10.1016/j.canlet.2007.10.036-
Appears in Collections:
College of Medicine/School of Medicine (의과대학/대학원)Surgery (외과학전공)Journal Papers (저널논문_외과학전공)
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