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High b-value diffusion (b = 3000 s/mm2) MR imaging in cerebral gliomas at 3T: visual and quantitative comparisons with b = 1000 s/mm2

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dc.contributor.authorSeo, H. S.-
dc.contributor.authorChang, K.-H.-
dc.contributor.authorNa, D. G.-
dc.contributor.authorKwon, B. J.-
dc.contributor.authorLee, D. H.-
dc.date.accessioned2010-04-07T07:42:05Z-
dc.date.available2010-04-07T07:42:05Z-
dc.date.issued2007-12-11-
dc.identifier.citationAJNR Am J Neuroradiol. 2008 ;29(3):458-63.en
dc.identifier.issn1936-959X (Electronic)-
dc.identifier.issn0195-6108 (Print)-
dc.identifier.urihttps://hdl.handle.net/10371/62644-
dc.description.abstractBACKGROUND AND PURPOSE: High b-value diffusion-weighted imaging (DWI) provides different features not appreciated at lower b-value and have been recently studied in several clinical issues. The purpose of this study was to assess whether DWI at b = 3000 s/mm(2) is more useful in discriminating high-grade and low-grade gliomas than DWI at b = 1000 s/mm(2) at 3T. MATERIALS AND METHODS: DWIs at both b = 1000 and 3000 s/mm(2) were performed at 3T in 62 patients, 49 high-grade gliomas (20 World Health Organization [WHO] grade III and 29 grade IV) and 13 low-grade gliomas (13 grade II). Visual assessments based on 5-point scaled evaluations, receiver operating characteristic (ROC) curve analysis, and quantitative assessment based on DWI signal intensity (SI) ratio (tumor SI/normal SI) and apparent diffusion coefficient (ADC) values were compared between DWIs at b = 1000 and 3000 s/mm(2). RESULTS: By visual assessment, DWI at b = 3000 s/mm(2) showed more conspicuous hyperintensity in high-grade gliomas and hypointensity in low-grade gliomas than DWI at b = 1000 s/mm(2). Sensitivity and specificity at b = 3000 s/mm(2) were higher than at b = 1000 s/mm(2) (83.7%, 84.6% vs 69.4%, 76.9%, respectively). Quantitative assessments showed that mean SI ratio of high-grade gliomas was significantly higher than that of low-grade gliomas at both b-values. The mean ADC value of high-grade gliomas was significantly lower than that of low-grade gliomas at both b-values. The difference between the SI ratios of high-grade and low-grade gliomas was significantly larger at b = 3000 s/mm(2) than at b = 1000 s/mm(2). CONCLUSION: DWI at b = 3000 s/mm(2) is more useful than DWI at b = 1000 s/mm(2) in terms of discriminating high-grade and low-grade gliomas at 3T.en
dc.language.isoenen
dc.publisherAmerican Society of Neuroradiologyen
dc.subjectAdolescenten
dc.subjectAdulten
dc.subjectAgeden
dc.subjectBrain/*pathologyen
dc.subjectBrain Neoplasms/*diagnosisen
dc.subjectChilden
dc.subjectDiffusion Magnetic Resonance Imaging/*methodsen
dc.subjectFemaleen
dc.subjectGlioma/*diagnosisen
dc.subjectHumansen
dc.subjectImage Enhancement/*methodsen
dc.subjectImage Interpretation, Computer-Assisted/*methodsen
dc.subjectMaleen
dc.subjectMiddle Ageden
dc.subjectReproducibility of Resultsen
dc.subjectSensitivity and Specificityen
dc.titleHigh b-value diffusion (b = 3000 s/mm2) MR imaging in cerebral gliomas at 3T: visual and quantitative comparisons with b = 1000 s/mm2en
dc.typeArticleen
dc.identifier.doi10.3174/ajnr.A0842-
Appears in Collections:
College of Medicine/School of Medicine (의과대학/대학원)Radiology (영상의학전공)Journal Papers (저널논문_영상의학전공)
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