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Fatigue and depression in disease-free breast cancer survivors: prevalence, correlates, and association with quality of life

Cited 147 time in Web of Science Cited 160 time in Scopus
Authors
Kim, Soo Hyun; Son, Byung Ho; Hwang, Sook Yeon; Han, Wonshik; Yang, Jung-Hyun; Lee, Seeyoun; Yun, Young Ho
Issue Date
2008-03-25
Publisher
Elsevier
Citation
J Pain Symptom Manage. 2008 ;35(6):644-55.
Keywords
AdultBreast Neoplasms/*psychologyData CollectionDepression/*epidemiology/etiologyFatigue/*epidemiology/etiologyFemaleHumansMiddle AgedPsychiatric Status Rating ScalesQuality of LifeSurvivors/*psychology
Abstract
We performed this study to examine the prevalence and correlates of fatigue and depression, and their relevance to health-related quality of life in disease-free breast cancer survivors. A total of 1,933 breast cancer survivors recruited from five large hospitals in Korea completed a mailed survey, which included the Brief Fatigue Inventory, Beck Depression Inventory, European Organization for Research and Treatment of Cancer QLQ-C30, and QLQ-BR23. With a framework that included sociodemographic, clinical, and symptom characteristics, multivariate logistic regression models were used to identify factors associated with fatigue and depression. Among breast cancer survivors, 66.1% reported moderate to severe fatigue and 24.9% reported moderate to severe depression. Risk factors common to both fatigue and depression were lower income, dyspnea, insomnia, appetite loss, constipation, and arm symptoms. Risk factors for fatigue only included younger age, employment, presence of gastrointestinal disease, and pain. Having a musculoskeletal disease was identified as a risk factor for depression only. Both fatigue and depression were influenced by sociodemographic factors, comorbidity and symptom characteristics rather than cancer or treatment-related factors. Both fatigue and depression were negatively associated with survivors' health-related quality of life. However, the patterns of differences in health-related quality of life according to severity of fatigue or depression were similar. This concurrent examination of risk factors for fatigue and depression may be helpful in the development of clinical management strategies in disease-free breast cancer survivors.
ISSN
0885-3924 (Print)
Language
English
URI
http://hdl.handle.net/10371/62818
DOI
https://doi.org/10.1016/j.jpainsymman.2007.08.012
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College of Medicine/School of Medicine (의과대학/대학원)Surgery (외과학전공)Journal Papers (저널논문_외과학전공)
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