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Paternal smoking, genetic polymorphisms in CYP1A1 and childhood leukemia risk
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, Kyoung-Mu | - |
dc.contributor.author | Ward, Mary H. | - |
dc.contributor.author | Han, Sohee | - |
dc.contributor.author | Ahn, Hyo Seop | - |
dc.contributor.author | Kang, Hyoung Jin | - |
dc.contributor.author | Choi, Hyung Soo | - |
dc.contributor.author | Shin, Hee Young | - |
dc.contributor.author | Koo, Hong-Hoe | - |
dc.contributor.author | Seo, Jong-Jin | - |
dc.contributor.author | Choi, Ji-Eun | - |
dc.contributor.author | Ahn, Yoon-Ok | - |
dc.contributor.author | Kang, Daehee | - |
dc.date.accessioned | 2010-04-13 | - |
dc.date.available | 2010-04-13 | - |
dc.date.issued | 2008-08-12 | - |
dc.identifier.citation | Leuk Res. 2009 ;33(2):250-8. | en |
dc.identifier.issn | 1873-5835 (Electronic) | - |
dc.identifier.issn | 0145-2126 (Print) | - |
dc.identifier.uri | https://hdl.handle.net/10371/63011 | - |
dc.description.abstract | We conducted a case-control study to evaluate the association between paternal smoking and childhood leukemia and to evaluate potential modification by polymorphisms in CYP1A1. Histologically confirmed childhood leukemia cases (n=164) and non-cancer controls (n=164) were recruited from three teaching hospitals in Seoul, Korea. Five single nucleotide polymorphisms in CYP1A1 (-17961T>C, -9893G>A, I462V, 1188C>T (*2A), and 11599C>G) were genotyped and haplotypes were estimated by the expectation-maximization method. We also conducted a meta-analysis of 12 studies that have reported the association between paternal smoking and childhood leukemia risk. Paternal smoking at home was associated with all leukemias (OR=1.8, 95% CI=1.1-2.8) and acute lymphoblastic leukemia (ALL) (2.0, 1.2-3.4). An increasing trend in risk was observed for pack-years smoked after birth (P(trend)=0.06 and 0.02, respectively) and the number of smokers in the home during the child's life (P(trend)=0.05 and 0.03, respectively). Among those without the CGACC haplotype, ALL risk was significantly increased by the father's smoking at home (2.8, 1.5-5.3) and the presence of at least one smoker in the home (2.3, 1.2-4.4), and the test for interaction was significant (P(interaction)=0.03 and 0.02, respectively). The meta-analysis showed that overall paternal smoking (1.13, 1.04-1.24) and smoking before the pregnancy of the child (1.12, 1.04-1.21) were significantly associated with childhood leukemia risk. Our results suggest that paternal smoking is a risk factor for childhood leukemia and the effect may be modified by CYP1A1 genotype. | en |
dc.language.iso | en | en |
dc.publisher | Elsevier | en |
dc.subject | Adolescent | en |
dc.subject | Case-Control Studies | en |
dc.subject | Child | en |
dc.subject | Child, Preschool | en |
dc.subject | Cytochrome P-450 CYP1A1/*genetics | en |
dc.subject | Environmental Exposure | en |
dc.subject | Female | en |
dc.subject | Genotype | en |
dc.subject | Haplotypes | en |
dc.subject | Humans | en |
dc.subject | Infant | en |
dc.subject | Leukemia/*etiology | en |
dc.subject | Male | en |
dc.subject | Polymorphism, Single Nucleotide | en |
dc.subject | Precursor Cell Lymphoblastic Leukemia-Lymphoma | en |
dc.subject | Risk Factors | en |
dc.subject | Smoking/*adverse effects | en |
dc.subject | Fathers | - |
dc.subject | Polymorphism, Genetic | - |
dc.title | Paternal smoking, genetic polymorphisms in CYP1A1 and childhood leukemia risk | en |
dc.type | Article | en |
dc.contributor.AlternativeAuthor | 이경무 | - |
dc.contributor.AlternativeAuthor | 한소희 | - |
dc.contributor.AlternativeAuthor | 안효섭 | - |
dc.contributor.AlternativeAuthor | 강형진 | - |
dc.contributor.AlternativeAuthor | 최형수 | - |
dc.contributor.AlternativeAuthor | 신희영 | - |
dc.contributor.AlternativeAuthor | 구홍회 | - |
dc.contributor.AlternativeAuthor | 서종진 | - |
dc.contributor.AlternativeAuthor | 최지은 | - |
dc.contributor.AlternativeAuthor | 안윤옥 | - |
dc.contributor.AlternativeAuthor | 강대희 | - |
dc.identifier.doi | 10.1016/j.leukres.2008.06.031 | - |
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