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Molded porous poly(L-lactide) membranes for guided bone regeneration with enhanced effects by controlled growth factor release

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Authors
Ku, Young; Lee, Seung Jin; Park, Yoon Jeong; Park, Si Nae; Lee, Yong Moo; Seol, Yang Jo; Chung, Chong Pyoung
Issue Date
2001-02
Publisher
Wiley-Blackwell
Citation
Journal of Biomedical Materials Research 2001;55:295-303.
Keywords
platelet-derived growth factor-BBpoly (L-lactide)-tricalcium phosphate (TCP) membranemolded membranecontrolled releaseguided bone regeneration
Abstract
The aim of this study was to develop platelet-derived growth factor (PDGF-BB) loaded moldable porous poly (L-lactide) (PLLA)-tricalcium phosphate (TCP) membranes for guided bone regeneration (GBR) therapy. The membranes were designed to fit various types of bone defect sites. PDGF-BB-dissolved PLLA-TCP in methylene chloride-ethyl acetate solution was cast on a dome shaped metallic mold to fabricate a model membrane. The release rate of PDGF-BB, the osteoblast attachment test, and guided bone regeneration potential were evaluated with PDGF-BB-loaded PLLA-TCP membranes. Regular pores were generated throughout the membrane mainly due to phase inversion of PLLA-methylene chloride-ethyl acetate solution. A therapeutic amount of PDGF-BB was released from the membrane. The release rate could be controlled by varying the initial loading content of PDGF-BB. A significant amount of cells attached onto the PDGF-BB-loaded membrane rather than onto the unloaded membrane. Dome shaped bone formation was achieved in rabbit calvaria at 4 weeks. This indicated that restoration of bone defects to the bone's original shape can be made possible by using molded membranes, which guide bone regeneration along with providing sufficient spaces. Bone forming efficiency was increased remarkably due to PDGF-BB release from PLLA-TCP membranes. These results suggested that the PDGF-BB releasing molded PLLA-TCP membrane may potentially improve GBR efficiency in various types of bone defects. © 2001 John Wiley & Sons, Inc. J Biomed Mater Res 55: 295-303, 2001
ISSN
1549-3296
Language
English
URI
https://hdl.handle.net/10371/63034
DOI
https://doi.org/10.1002/1097-4636(20010605)55:3<295::AID-JBM1017>3.0.CO;2-W
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College of Dentistry/School of Dentistry (치과대학/치의학대학원)Dept. of Dentistry (치의학과)Journal Papers (저널논문_치의학과)
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