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The heme oxygenase-1 genotype is a risk factor to renal impairment of IgA nephropathy at diagnosis, which is a strong predictor of mortality
DC Field | Value | Language |
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dc.contributor.author | Chin, Ho Jun | - |
dc.contributor.author | Cho, Hyun Jin | - |
dc.contributor.author | Lee, Tae Woo | - |
dc.contributor.author | Na, Ki Young | - |
dc.contributor.author | Yoon, Hyung Jin | - |
dc.contributor.author | Chae, Dong-Wan | - |
dc.contributor.author | Kim, Suhnggwon | - |
dc.contributor.author | Jeon, Un Sil | - |
dc.contributor.author | Do, Jun-Young | - |
dc.contributor.author | Park, Jong-Won | - |
dc.contributor.author | Yoon, Kyung-Woo | - |
dc.contributor.author | Shin, Young-Tai | - |
dc.contributor.author | Lee, Kang Wook | - |
dc.contributor.author | Na, Ki-Ryang | - |
dc.contributor.author | Cha, Dae Ryong | - |
dc.contributor.author | Kang, Young Sun | - |
dc.date.accessioned | 2010-04-13T04:49:35Z | - |
dc.date.available | 2010-04-13T04:49:35Z | - |
dc.date.issued | 2009-02-12 | - |
dc.identifier.citation | J Korean Med Sci. 2009 Jan;24 Suppl:S30-7. Epub 2009 Jan 28. | en |
dc.identifier.issn | 1011-8934 (Print) | - |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=19194559 | - |
dc.identifier.uri | http://synapse.koreamed.org/Synapse/Data/PDFData/0063JKMS/jkms-24-S30.pdf | - |
dc.identifier.uri | https://hdl.handle.net/10371/63096 | - |
dc.description.abstract | The induction of heme oxygenase-1 (HO-1) ameliorates oxidative stress and inflammatory process, which play important roles in IgA nephropathy. We hypothesized length polymorphism in the promoter region of the HO-1 gene, which is related to the level of gene transcription, is associated with disease severity of IgA nephropathy. The subjects comprised 916 patients with IgA nephropathy and gene data. Renal impairment was defined as an estimated glomerular filtration rate less than 60 mL/min/1.73 m(2) at diagnosis. The short (S: <23), medium (M: 23-28), and long (L: >28) (GT) repeats in the HO-1 gene was determined. The frequencies of S/S, S/M, M/M, S/L, L/M, and L/L genotypes were 7.2%, 6.9%, 3.1%, 30.8%, 22.7%, and 29.4%, respectively. The baseline characteristics were not different. In the S/S genotypic group, the renal impairment rate was 18.2%, which was lower than 32.2% in the group with M/M, L/M, or L/L genotype. The odds ratio of renal impairment in S/S genotype, compared to that in M/M, L/M, or L/L genotype, was 0.216 (95% confidence interval, 0.060-0.774, p=0.019). The HO-1 gene promoter length polymorphism was related to the renal impairment of IgA nephropathy at diagnosis, which is an important risk factor for mortality in IgA nephropathy patients. | en |
dc.language.iso | en | en |
dc.publisher | Korean Academy of Medical Science | en |
dc.subject | Adult | en |
dc.subject | Disease Progression | en |
dc.subject | Female | en |
dc.subject | Gene Frequency | en |
dc.subject | Genotype | en |
dc.subject | Glomerular Filtration Rate | en |
dc.subject | Glomerulonephritis, IGA/*genetics/mortality/*pathology | en |
dc.subject | Heme Oxygenase-1/*genetics | en |
dc.subject | Humans | en |
dc.subject | Male | en |
dc.subject | Middle Aged | en |
dc.subject | Odds Ratio | en |
dc.subject | Polymorphism, Genetic | en |
dc.subject | Promoter Regions, Genetic | en |
dc.subject | Risk Factors | en |
dc.title | The heme oxygenase-1 genotype is a risk factor to renal impairment of IgA nephropathy at diagnosis, which is a strong predictor of mortality | en |
dc.type | Article | en |
dc.contributor.AlternativeAuthor | 진호준 | - |
dc.contributor.AlternativeAuthor | 조현진 | - |
dc.contributor.AlternativeAuthor | 이태우 | - |
dc.contributor.AlternativeAuthor | 나기영 | - |
dc.contributor.AlternativeAuthor | 윤형진 | - |
dc.contributor.AlternativeAuthor | 채동완 | - |
dc.contributor.AlternativeAuthor | 김성권 | - |
dc.contributor.AlternativeAuthor | 전은실 | - |
dc.contributor.AlternativeAuthor | 도준영 | - |
dc.contributor.AlternativeAuthor | 박종원 | - |
dc.contributor.AlternativeAuthor | 윤경우 | - |
dc.contributor.AlternativeAuthor | 신영태 | - |
dc.contributor.AlternativeAuthor | 이강욱 | - |
dc.contributor.AlternativeAuthor | 나기량 | - |
dc.contributor.AlternativeAuthor | 차대룡 | - |
dc.contributor.AlternativeAuthor | 강영선 | - |
dc.identifier.doi | 10.3346/jkms.2009.24.S1.S30 | - |
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