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The heme oxygenase-1 genotype is a risk factor to renal impairment of IgA nephropathy at diagnosis, which is a strong predictor of mortality

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dc.contributor.authorChin, Ho Jun-
dc.contributor.authorCho, Hyun Jin-
dc.contributor.authorLee, Tae Woo-
dc.contributor.authorNa, Ki Young-
dc.contributor.authorYoon, Hyung Jin-
dc.contributor.authorChae, Dong-Wan-
dc.contributor.authorKim, Suhnggwon-
dc.contributor.authorJeon, Un Sil-
dc.contributor.authorDo, Jun-Young-
dc.contributor.authorPark, Jong-Won-
dc.contributor.authorYoon, Kyung-Woo-
dc.contributor.authorShin, Young-Tai-
dc.contributor.authorLee, Kang Wook-
dc.contributor.authorNa, Ki-Ryang-
dc.contributor.authorCha, Dae Ryong-
dc.contributor.authorKang, Young Sun-
dc.date.accessioned2010-04-13T04:49:35Z-
dc.date.available2010-04-13T04:49:35Z-
dc.date.issued2009-02-12-
dc.identifier.citationJ Korean Med Sci. 2009 Jan;24 Suppl:S30-7. Epub 2009 Jan 28.en
dc.identifier.issn1011-8934 (Print)-
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=19194559-
dc.identifier.urihttp://synapse.koreamed.org/Synapse/Data/PDFData/0063JKMS/jkms-24-S30.pdf-
dc.identifier.urihttps://hdl.handle.net/10371/63096-
dc.description.abstractThe induction of heme oxygenase-1 (HO-1) ameliorates oxidative stress and inflammatory process, which play important roles in IgA nephropathy. We hypothesized length polymorphism in the promoter region of the HO-1 gene, which is related to the level of gene transcription, is associated with disease severity of IgA nephropathy. The subjects comprised 916 patients with IgA nephropathy and gene data. Renal impairment was defined as an estimated glomerular filtration rate less than 60 mL/min/1.73 m(2) at diagnosis. The short (S: <23), medium (M: 23-28), and long (L: >28) (GT) repeats in the HO-1 gene was determined. The frequencies of S/S, S/M, M/M, S/L, L/M, and L/L genotypes were 7.2%, 6.9%, 3.1%, 30.8%, 22.7%, and 29.4%, respectively. The baseline characteristics were not different. In the S/S genotypic group, the renal impairment rate was 18.2%, which was lower than 32.2% in the group with M/M, L/M, or L/L genotype. The odds ratio of renal impairment in S/S genotype, compared to that in M/M, L/M, or L/L genotype, was 0.216 (95% confidence interval, 0.060-0.774, p=0.019). The HO-1 gene promoter length polymorphism was related to the renal impairment of IgA nephropathy at diagnosis, which is an important risk factor for mortality in IgA nephropathy patients.en
dc.language.isoenen
dc.publisherKorean Academy of Medical Scienceen
dc.subjectAdulten
dc.subjectDisease Progressionen
dc.subjectFemaleen
dc.subjectGene Frequencyen
dc.subjectGenotypeen
dc.subjectGlomerular Filtration Rateen
dc.subjectGlomerulonephritis, IGA/*genetics/mortality/*pathologyen
dc.subjectHeme Oxygenase-1/*geneticsen
dc.subjectHumansen
dc.subjectMaleen
dc.subjectMiddle Ageden
dc.subjectOdds Ratioen
dc.subjectPolymorphism, Geneticen
dc.subjectPromoter Regions, Geneticen
dc.subjectRisk Factorsen
dc.titleThe heme oxygenase-1 genotype is a risk factor to renal impairment of IgA nephropathy at diagnosis, which is a strong predictor of mortalityen
dc.typeArticleen
dc.contributor.AlternativeAuthor진호준-
dc.contributor.AlternativeAuthor조현진-
dc.contributor.AlternativeAuthor이태우-
dc.contributor.AlternativeAuthor나기영-
dc.contributor.AlternativeAuthor윤형진-
dc.contributor.AlternativeAuthor채동완-
dc.contributor.AlternativeAuthor김성권-
dc.contributor.AlternativeAuthor전은실-
dc.contributor.AlternativeAuthor도준영-
dc.contributor.AlternativeAuthor박종원-
dc.contributor.AlternativeAuthor윤경우-
dc.contributor.AlternativeAuthor신영태-
dc.contributor.AlternativeAuthor이강욱-
dc.contributor.AlternativeAuthor나기량-
dc.contributor.AlternativeAuthor차대룡-
dc.contributor.AlternativeAuthor강영선-
dc.identifier.doi10.3346/jkms.2009.24.S1.S30-
Appears in Collections:
College of Medicine/School of Medicine (의과대학/대학원)Internal Medicine (내과학전공)Journal Papers (저널논문_내과학전공)
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