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Protective role of CYP1A1*2A in the development of multiple myeloma

Cited 15 time in Web of Science Cited 17 time in Scopus
Authors
Kang, Seong-Ho; Kim, Tae Young; Kim, Ho Young; Yoon, Jong-Hyun; Cho, Han-Ik; Yoon, Sung Soo; Kang, Dae Hee; Suh, Cheol Won; Lee, Jae Hoon; Lee, Dong Soon
Issue Date
2008-02-21
Publisher
Karger
Citation
Acta Haematol. 2008;119(1):60-4. Epub 2008 Feb 20.
Keywords
AllelesBase SequenceCytochrome P-450 CYP1A1/*geneticsDNA PrimersGenetic Predisposition to DiseaseHumansMultiple Myeloma/*enzymology/*genetics/pathologyPolymerase Chain Reaction*Polymorphism, Single Nucleotide
Abstract
We had previously reported the association of the NQO1*2/*2 polymorphism with a decreased risk for multiple myeloma (MM) in Koreans (odds ratio, OR, 0.24; 95% confidence interval, CI, 0.01-0.68). The associations of polymorphisms of other metabolizing enzymes (CYP1A1, GSTM1 and GSTT1) with the MM risk were investigated in 116 Korean MM patients and 176 Korean controls using TaqMan allelic discrimination and multiplex polymerase chain reaction. The ORs for CYP1A1*1/*2A and CYP1A1*1/*2B genotypes were 0.43 (95% CI, 0.19-0.98) and 0.51 (95% CI, 0.26-0.98), respectively, which was significantly associated with a decreased MM risk. With regard to CYP1A1 alleles, the OR for the CYP1A1*2A allele was 0.57 (95% CI, 0.326-0.995), which was also significantly associated with a decreased MM risk. However, null types of GSTM1 and GSTT1 polymorphisms were not associated with the MM risk. These results were different from those of a previous report on Caucasians which suggested the association of the GSTT1 polymorphism with an increased MM risk and no association of CYP1A1 with the MM risk. The associations of polymorphisms of metabolizing enzymes with the risk for MM differed between Koreans and Caucasians, suggesting an ethnic variation in the susceptibility to MM.
ISSN
1421-9662 (Electronic)
1421-9662 (Linking)
Language
English
URI
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=18285692

http://content.karger.com/ProdukteDB/produkte.asp?Aktion=ShowPDF&ArtikelNr=000117572&Ausgabe=234243&ProduktNr=223829&filename=000117572.pdf

https://hdl.handle.net/10371/63106
DOI
https://doi.org/10.1159/000117572
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College of Medicine/School of Medicine (의과대학/대학원)Laboratory Medicine (검사의학전공)Journal Papers (저널논문_검사의학전공)
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