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Effect of electroacupuncture on motor recovery in a rat stroke model during the early recovery stage

Cited 23 time in Web of Science Cited 20 time in Scopus
Authors
Kim, Won-Seok; Kim, Il Soo; Kim, Sang Jun; Wei, PengXu; Choi, Deok Hyung; Han, Tai Ryoon
Issue Date
2008-12-02
Publisher
Elsevier
Citation
Brain Res. 2009 ;1248:176-83.
Keywords
Analysis of VarianceAnimalsBlotting, WesternBrain IschemiaBrain-Derived Neurotrophic Factor/metabolismDisease Models, Animal*ElectroacupunctureExercise TherapyInfarction, Middle Cerebral Artery/metabolism/rehabilitationMale*Motor ActivityRatsReceptor, trkB/metabolism*Recovery of FunctionStroke/metabolism/*rehabilitationVertebral Artery
Abstract
The effect of acupuncture on motor recovery after stroke continues to be debated. This animal study was designed to determine whether acupuncture improves motor function following experimentally induced cerebral ischemia. In addition, we studied whether the outcome of motor function was associated with the expression of BDNF (brain derived neurotrophic factor), trkB (receptor, trkB) and infarct volume. Cerebral ischemia was induced by permanent middle cerebral artery occlusion (MCAO) or MCAO plus bilateral vertebral artery occlusion in Sprague-Dawley rats. The groups studied were a control, treadmill exercise, electroacupuncture and a combined treatment group with both treadmill exercise and electroacupuncture (ExEA). On postoperative day 16, Western blot analysis for BDNF and trkB and estimation of infarct volume were performed. The motor behavior scores were measured 2 and 16-days postoperatively. Comparison of the motor scores among the groups showed that the motor scores in the exercise only group and ExEA group were higher than in the control group on postoperative day 16. No statistical significance was found among the groups in the Western blot analysis and the infarct volume. This study demonstrates no significant additional effect of electroacupuncture on the motor recovery in rats following mild cerebral ischemia during the early recovery stage. Further studies in a rat model with moderate to severe cerebral ischemia, assessment and reassessment for more extended periods after the cerebral ischemia will be required.
ISSN
1872-6240 (Electronic)
0006-8993 (Print)
Language
English
URI
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=19041635

https://hdl.handle.net/10371/63123
DOI
https://doi.org/10.1016/j.brainres.2008.11.009
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College of Medicine/School of Medicine (의과대학/대학원)Rehabilitation Medicine (재활의학전공)Journal Papers (저널논문_재활의학전공)
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