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Effects of 24-Hour Starvation on the Lipid Content of Carbon Tetrachloride-Induced Fatty Liver in Mice
24시간 기아가 4염화탄소(CCl4)중독마우스간장의 각종태질함량에 미치는 영향에 관한 연구

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Authors
Bang, Suck Woon; Lee, Ki Yung
Issue Date
1968-12
Publisher
서울대학교 의과대학
Citation
Seoul J Med, Vol.9 No.4, pp. 1-13
Abstract
Lipid contents of carbon tetrachloride-induced
fatty liver in mice were studied by placing the
animals under 24-hour fast immediately after or
prior to the intraperitoneal administration of the
hepatotoxic agent or control substance. The
following major points became evident from our
studies.
1. previous or consecutive 24-hour fast with
intraperitoneal injection of carbon tetrachloride
induced accumulation of greater amounts of liver
triglycerides than the simple administration of
the hepatotoxic agent or 24-hour fasting alone
would.
2. On the basis of our findings above, the
requirement of free fatty acids for the development
of fatty liver in carbon tetrachloride poisoning,
apart from being a direct cause, seems
inevitable.
In addition to these major conclusions, other
gleanings obtained from our works were as
follows.
1. The loss of liver weight by simple fasting
in mice for 24 hours was by ca 10% and for
30 hours by ca 12%, of each control.
2. The gain in unit weight liver triglyceride
content had already shown up by 6 hours after
the induction of fasting and reached apparent
plateau by 24-30 hours in relation to time course
observed in two separate experiments.
3. The administration of carbon tetrachloride
coupled with previous or ensuing starvation
raised the unit weight liver total cholesterol
content to a statistically significant extent; and
fasting seemed to be dominating in effect over
the action of carbon tetrachloride.
4. The unit weight liver phospholipid content
was generally inversely proportional to the total
liver weight except in the animal group admi-nistered carbon tetrachloride with subsequent
24-hour fasting, in which group the phospholipid
increase had in part contributed to the liver
weight gain.
5. The unit weight liver glycogen content was
most markedly decreased by the combined action
of carbon tetrachloride administration and prev
ious or subsequent fasting than any other experimental
conditions set forth; however, the glycogen
depleting action of carbon tetrachloride
seemed to be superior to that of 24-hour fasting.
ISSN
0582-6802
Language
Korean
URI
https://hdl.handle.net/10371/6327
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College of Medicine/School of Medicine (의과대학/대학원)Dept. of Medicine (의학과)The Seoul Journal of MedicineThe Seoul Journal of Medicine Vol. 09 No.4 (1968)
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