Browse

The effect of acamprosate on alcohol and food craving in patients with alcohol dependence

DC Field Value Language
dc.contributor.authorHan, Doug Hyun-
dc.contributor.authorLyool, In Kyoon-
dc.contributor.authorSung, Young Hoon-
dc.contributor.authorLee, Sang Hoon-
dc.contributor.authorRenshaw, Perry F.-
dc.date.accessioned2010-04-19-
dc.date.available2010-04-19-
dc.date.issued2007-11-07-
dc.identifier.citationDrug Alcohol Depend. 2008 ;93(3):279-83.en
dc.identifier.issn0376-8716 (Print)-
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=17983709-
dc.identifier.urihttps://hdl.handle.net/10371/63309-
dc.description.abstractINTRODUCTION: The balance between inhibitory (gamma aminobutyric acid; GABAergic) and excitatory (glutamatergic) neurotransmission is thought to be associated with craving for alcohol and food. The anticraving effect of acamprosate is thought to be mediated through modifying the balance of GABA and glutamate. Recent studies in animals have suggested that acamprosate may have non-selective effects on craving for both alcohol and food. METHODS: The influence of acamprosate for reducing craving for alcohol and food was assessed in 204 in-patients with alcohol dependence (96 patients treated with acamprosate, PWA; 108 patients were not treated PNA) was assessed at baseline and following 1, 2, and 4 weeks of treatment. RESULTS: There was a significant reduction in craving for alcohol over 4 weeks of treatment in both PWA and PNA groups, but without significant group differences. In contrast, a reduction in food craving was observed only in the PWA group. In addition, there was a significant increase of body mass index (BMI) in the PNA group but not the PWA group over the 4-week period. DISCUSSION: These results demonstrate acamprosate nonselective effects on craving for drinking and eating in alcoholic patients.en
dc.language.isoenen
dc.publisherElsevieren
dc.subjectAdulten
dc.subjectAlcohol Deterrents/*therapeutic useen
dc.subjectAlcoholism/complications/*drug therapy/*psychologyen
dc.subjectBody Mass Indexen
dc.subjectCognitive Therapyen
dc.subjectCohort Studiesen
dc.subjectCombined Modality Therapyen
dc.subjectEating Disorders/complications/*drug therapy/*psychologyen
dc.subjectFemaleen
dc.subject*Fooden
dc.subjectGABA Modulators/therapeutic useen
dc.subjectHumansen
dc.subjectLorazepam/therapeutic useen
dc.subjectMaleen
dc.subjectMiddle Ageden
dc.subjectPsychiatric Status Rating Scalesen
dc.subjectSocioeconomic Factorsen
dc.subjectTaurine/*analogs & derivatives/therapeutic useen
dc.subjectThiamine/therapeutic useen
dc.titleThe effect of acamprosate on alcohol and food craving in patients with alcohol dependenceen
dc.typeArticleen
dc.contributor.AlternativeAuthor한동현-
dc.contributor.AlternativeAuthor성영훈-
dc.contributor.AlternativeAuthor이상훈-
dc.identifier.doi10.1016/j.drugalcdep.2007.09.014-
Appears in Collections:
College of Medicine/School of Medicine (의과대학/대학원)Psychiatry (정신과학전공)Journal Papers (저널논문_정신과학전공)
Files in This Item:
There are no files associated with this item.
  • mendeley

Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse