Publications
Detailed Information
Taq1A polymorphism in the dopamine D2 receptor gene as a predictor of clinical response to aripiprazole
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kwon, Jun Soo | - |
dc.contributor.author | Kim, Euitae | - |
dc.contributor.author | Kang, Do-Hyung | - |
dc.contributor.author | Choi, Jung Seok | - |
dc.contributor.author | Yu, Kyung-Sang | - |
dc.contributor.author | Jang, In-Jin | - |
dc.contributor.author | Shin, Sang-Goo | - |
dc.date.accessioned | 2010-04-19T01:44:59Z | - |
dc.date.available | 2010-04-19T01:44:59Z | - |
dc.date.issued | 2008-09-13 | - |
dc.identifier.citation | Eur Neuropsychopharmacol. 2008 ;18(12):897-907. | en |
dc.identifier.issn | 0924-977X (Print) | - |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=18786813 | - |
dc.identifier.uri | https://hdl.handle.net/10371/63330 | - |
dc.description.abstract | We investigated whether the clinical response to aripiprazole differed according to the Taq1A polymorphism in the dopamine D2 receptor (DRD2) gene. In this 26-week, prospective, open-label, double-blind, parallel-group study, 90 patients with schizophrenia, schizoaffective disorder, or schizophreniform disorder were recruited and divided into two groups according to their DRD2 genotype (A1A1, n=14; A1A2+A2A2, n=76). The efficacy assessment included Positive and Negative Syndrome Scale (PANSS) scores and Clinical Global Impression (CGI) scores. Extrapyramidal symptoms were assessed using the Simpson-Angus Scale (SAS), Abnormal Involuntary Movement Scale (AIMS), and Barnes Akathisia Rating Scale (BAS). Plasma prolactin levels were also measured. Patients with the A1A1 genotype showed a more favorable therapeutic response to aripiprazole when assessed using the PANSS ratio. The changes in the SAS score from baseline to week 4 also differed according to the genotype group. There were no significant differences in the changes in the CGI, AIMS, and BAS scores or plasma prolactin level between the two genotype groups. The results suggest an association between the DRD2 Taq1A polymorphism status and the variation in the clinical response to aripiprazole. | en |
dc.language.iso | en | en |
dc.publisher | Elsevier | en |
dc.subject | Adolescent | en |
dc.subject | Adult | en |
dc.subject | Aged | en |
dc.subject | Antidepressive Agents/therapeutic use | en |
dc.subject | Antipsychotic Agents/*therapeutic use | en |
dc.subject | Double-Blind Method | en |
dc.subject | Female | en |
dc.subject | Follow-Up Studies | en |
dc.subject | Genotype | en |
dc.subject | Humans | en |
dc.subject | Male | en |
dc.subject | Middle Aged | en |
dc.subject | Piperazines/*therapeutic use | en |
dc.subject | Prolactin/blood | en |
dc.subject | Prospective Studies | en |
dc.subject | Psychiatric Status Rating Scales | en |
dc.subject | Quinolones/*therapeutic use | en |
dc.subject | Receptors, Dopamine D2/*genetics | en |
dc.subject | Young Adult | en |
dc.subject | Polymorphism, Genetic | - |
dc.subject | Psychotic Disorders/drug therapy/genetics/physiopathology | - |
dc.subject | Schizophrenia/drug therapy/genetics/physiopathology | - |
dc.title | Taq1A polymorphism in the dopamine D2 receptor gene as a predictor of clinical response to aripiprazole | en |
dc.type | Article | en |
dc.contributor.AlternativeAuthor | 권준수 | - |
dc.contributor.AlternativeAuthor | 김의태 | - |
dc.contributor.AlternativeAuthor | 강도형 | - |
dc.contributor.AlternativeAuthor | 최정석 | - |
dc.contributor.AlternativeAuthor | 유경상 | - |
dc.contributor.AlternativeAuthor | 장인진 | - |
dc.contributor.AlternativeAuthor | 신상구 | - |
dc.identifier.doi | 10.1016/j.euroneuro.2008.07.010 | - |
- Appears in Collections:
- Files in This Item:
- There are no files associated with this item.
Item View & Download Count
Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.