S-Space College of Medicine/School of Medicine (의과대학/대학원) Psychiatry (정신과학전공) Journal Papers (저널논문_정신과학전공)
Loss of asymmetry in D2 receptors of putamen in unaffected family members at increased genetic risk for schizophrenia
- Lee, K J; Lee, J S; Kim, S J; Correll, C U; Wee, H; Yoo, S Y; Jeong, J M; Lee, D S; Lee, S I; Kwon, J S
- Issue Date
- Acta Psychiatr Scand. 2008 ;118(3):200-8.
- Adolescent; Adult; Brain/physiopathology/radionuclide imaging; Cognition Disorders/diagnosis/genetics/psychology; Family/*psychology; Female; Functional Laterality/*genetics; Genetic Markers/genetics; Genetic Predisposition to Disease/*psychology; Humans; Imaging, Three-Dimensional; Magnetic Resonance Imaging; Male; Neuropsychological Tests/statistics & numerical data; Positron-Emission Tomography/methods; Putamen/*physiopathology; Receptors, Dopamine D2/*genetics; Schizophrenia/*genetics; Young Adult
- OBJECTIVE: Dopamine dysregulation has been implicated in the pathophysiology of schizophrenia. The present study was performed to examine whether unaffected relatives at high genetic risk of schizophrenia have dopamine dysregulation in comparison with healthy controls. METHOD: Eleven unaffected relatives from families with two or more first- or second-degree relatives with schizophrenia (n = 9) or with a monozygotic schizophrenic twin (n = 2) and 11 age- and sex-matched controls were examined using positron emission tomography (PET) with [(11)C] raclopride. Subjects also underwent extensive neuropsychological testing. RESULTS: Subjects with high genetic risk showed a loss of asymmetry of D(2) receptors in the putamen in comparison with healthy controls. In addition, they showed significantly poorer performance on neuropsychological tests than controls. CONCLUSION: Our results suggest that dopamine dysregulation and neuropsychological dysfunction may be present in subjects at high genetic risk of schizophrenia. However, further studies are required to confirm these findings.
- 1600-0447 (Electronic)
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