S-Space College of Medicine/School of Medicine (의과대학/대학원) Psychiatry (정신과학전공) Journal Papers (저널논문_정신과학전공)
Probable case of neuroleptic malignant syndrome following administration of antituberculotic drugs in a chlorpromazine-treated patient
- Issue Date
- Korean Academy of Medical Sciences
- J Korean Med Sci. 2008 ;23(4):734-6.
- Adult ; Antitubercular Agents/*adverse effects ; Chlorpromazine/*adverse effects ; Creatine Kinase/blood ; Drug Interactions ; Enzyme Induction/drug effects ; Humans ; Male ; Neuroleptic Malignant Syndrome/*etiology ; Rifampin/*adverse effects ; Schizophrenia/*drug therapy
- Neuroleptic malignant syndrome (NMS), a potentially fatal adverse reaction to neuroleptics, is known to occur more often in the initial stage of antipsychotic treatment. We describe a patient with chronic schizophrenia who, in a few days after the addition of antituberculotic drugs to his antipsychotic regimen, developed probable NMS without pyrexia. We reasoned that rifampin, a strong hepatic enzyme inducer, decreased the plasma chlorpromazine concentration of the patient, with the result of cholinergic hyperactivity and finally, the symptoms of NMS. Therefore, physicians should be aware of drug interactions and the likelihood of NMS, and consider antipsychotic dose adjustment when prescribing drugs that may influence pharmacokinetic properties of antipsychotics in a patient with schizophrenia receiving long-term antipsychotic treatment.
- 1011-8934 (Print)