S-Space College of Medicine/School of Medicine (의과대학/대학원) Dept. of Medicine (의학과) The Seoul Journal of Medicine The Seoul Journal of Medicine Vol. 29 No.1 (1988)
The Effects of Sodium Salicylate on the Cochlea of Young Rats;A Structural Study
살리실산 나트륨이 백서(白鼠) 와우(蝸牛)의 미세구조에 미치는 영향에 관한 연구
- Ahn, Young Min; Lee, Byung Lan; Moon, Hyung Ro
- Issue Date
- Seoul J Med, Vol.29 No.1, pp. 31-38
- The ototoxicity of salicylate has been known and studied for many years.
However, there are many discrepancies about the site and mechanism of ototoxic effects of
salicylate on the cochlear structure. In order to investigate the ultrastructural changes of the
cochlea, high doses of sodium salicylate (500-600 mg/Kg, once a day for 5-7 days) were injected
subcutaneously to Sprague-Dawley rats weighing 80-120 gm. The organ of Corti and
the stria vascularis were examined under scanning and transmission electron microscopes. Extensive
vacuolization which forms characteristic blisters of the cell surface was observed in the
outer hir cells. Both in the outer and inner hair cells disarrangement of the stereocilia was
seen. It appeared that the apical portions of the cochlea showed more severe changes of
stereocilia than basal portions. The stria vascularis did not reveal any distinctive changes.
It was concluded that the ototoxicity of salicylate caused the ultrastrutural changes of hair
cells in the organ of Corti of rat cochlea and that outer hair cells were more susceptible than
the inner hair cells.