Browse

Controlled release of platelet-derived growth factor from porous poly(L-lactide) membranes for guided tissue regeneration

Cited 68 time in Web of Science Cited 79 time in Scopus
Authors
Park, Yoon Jeong; Ku, Young; Chung, Chong Pyoung; Lee, Seung Jin
Issue Date
1998-02-12
Publisher
Elsevier
Citation
Journal of Controlled Release 51 (1998) 201–211
Keywords
Platelet-derived growth factorpoly (L-lactide) membraneControlled releaseGuided tissue regeneration
Abstract
Platelet-derived growth factor-BB (PDGF-BB) was incorporated into porous poly
(L-lactide) (PLLA) membranes with an aim of improving early bone healing in guided tissue regeneration (GTR) therapy. Porous PDGF-BB loaded membranes were fabricated by coating PDGF-BB-dissolved PLLA methylene chloride–ethyl acetate solutions on polyglycolic acid (PGA) meshes. Release kinetics of PDGF-BB, biologic activity, degradability and guided tissue regenerative potentials of the membranes were investigated. Release of PDGF-BB could be controlled by adding bovine serum albumin that may provide porous diffusion channels for PDGF-BB release and by varying initial loading content of PDGF-BB. Biologic activity of PDGF-BB in the membranes was ascertained by fibroblast chemotaxis. PDGF-BB loaded membranes maintained proper degradation property for periodontal application. PDGF-BB loaded membrane markedly increased new bone formation in rat calvarial defects, and completed bony reunion after 2 weeks of implantation period. These results suggested that PDGF-BB loaded PLLA membrane might potentially enhance guided tissue regenerative efficacy.
ISSN
0168-3659
Language
English
URI
https://hdl.handle.net/10371/63628
DOI
https://doi.org/10.1016/S0168-3659(97)00169-7
Files in This Item:
There are no files associated with this item.
Appears in Collections:
College of Dentistry/School of Dentistry (치과대학/치의학대학원)Dept. of Dentistry (치의학과)Journal Papers (저널논문_치의학과)
  • mendeley

Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse