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Osteogenic abilities of bone marrow stromal cells are not defective in patients with osteonecrosis

Cited 17 time in Web of Science Cited 17 time in Scopus
Authors
Yoo, Jeong Joon; Song, Won Seok; Koo, Kyung-Hoi; Yoon, Kang Sup; Kim, Hee Joong
Issue Date
2008-02-20
Publisher
Springer Verlag
Citation
Int Orthop. 2009 ;33(3):867-72.
Keywords
AdultAgedAlkaline Phosphatase/metabolismBone Marrow Cells/*pathology/physiologyCalcification, Physiologic/physiologyCalcium/metabolismCell ProliferationCells, CulturedFemaleFemur Head Necrosis/metabolism/*pathologyHumansMaleMiddle AgedOsteogenesis/*physiologyStromal Cells/pathology/physiologyYoung Adult
Abstract
We investigated whether the proliferation activities and osteogenic capacities of bone marrow stromal cells (BMSCs) are depressed in patients with osteonecrosis of the femoral head (ONFH). BMSCs were isolated from fresh bone marrow of the iliac crests of 54 donors and were differentiated into osteogenic lineage in vitro. The results of 27 consecutive patients with ONFH (16 idiopathic and 11 alcohol-induced) were compared with those of 27 patients with a nonnecrotic hip disorder. The proliferative activities of BMSCs in patients with ONFH were not found to be reduced and their osteogenic capacities (alkaline phosphatase activity and calcium deposition amount) were unaltered during in vitro differentiation. Results from patients with idiopathic or alcohol-induced ONFH were similar to those of matched patients with nonnecrotic disorder. These findings suggest that the osteogenic potentials of BMSCs are not defective in patients with ONFH.
ISSN
1432-5195 (Electronic)
Language
English
URI
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=18283456

https://hdl.handle.net/10371/63632
DOI
https://doi.org/10.1007/s00264-008-0524-0
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College of Medicine/School of Medicine (의과대학/대학원)Orthopedic Surgery (정형외과학전공)Journal Papers (저널논문_정형외과학전공)
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