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Morphological Development of the Human Hypophysis : 뇌하수체의 형태학적 발달
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- Authors
- Issue Date
- 1988-06
- Citation
- Seoul J Med, Vol.29 No.2, pp. 119-130
- Keywords
- Adenohypophysis ; Neurohypophysis ; Development ; Embryo
- Abstract
- The morphological development of the human hypophysis was studied using
142 developing human hypophyses from 19 embryos and 123 fetuses. The adenohypophysis
first developed at 4 weeks of gestational age as an upward growing fold of the primitive oral
ectoderm Rathke's pouch. At 7 weeks, the configuration of pars distalis and pars intermedia
was formed. The Rathke's pouch lost its connection with the oral cavity completely at 8
weeks. Pars tuberalis became evident at 9 weeks. Histologically, capillary formation was found
at the end of 7 weeks in adenohypophysis and basophilic lamellated bodies were first identified
at 8 weeks. Cells with eosinophilic cytoplasm appeared at 9 weeks and those with
basophilic cytoplasm appeared between 10-12 weeks.
The neurohypophysis developed as a downward evagination of the diencephalic floor at 6
weeks. After 9 weeks, capillary formation occurred in the stroma, and primitive neuroepithelial
cells became differentiated. Ependymal tubules were also observed at this time. Between
25-29 weeks, suspicious pigment was seen in the cytoplasm of pituicytes and glial cell modification
into pituicytes seemed completed. No Herring body-like structures could be identified
throughout the fetal period.
- ISSN
- 0582-6802
- Language
- English
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