Clinical Usefulness of Tumor-Associated Antigen TA-4 In Cancer of the Uterine Cervix : 자궁경부암 환자에 있어서 종양관련 항원 TA-4에 관한 연구

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Yoon, Bo-Hyun; Kim, Syng-Wook; Koh, Chang-Soon

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Seoul National University College of Medicine
Seoul J Med, Vol.26 No.2, pp. 239-246
TA-4Squamous cell carcinomaUterine cervix
To evaluate the clinical usefulness of tumor antigen TA-4 as a tumor marker in
cervical cancer, serum TA-4 level was measured in 62 normal female subjects. 70 patients
with cervical cancer and 49 patients with various benign or malignant gynecologic diseases.
Mean serum TA-4 level in normal subjects was 0.42 ±0.22 ng/ml, and postive value was
considered to be greater than 1.5 ng/ml. The pretreatment positive rate of serum TA-4 was
42% in cervical squamous cell carcinoma, none in cervical adenocarcinoma. 33% in ovarian
cancer, 10% in cervical dysplasia and none in other diseases. In cervical squamous cell
carcinoma, the mean value of individual serum TA-4 as well as the percentage of patients
with positive TA-4 were positively related to clinical stage based on the FIGO system and to
the extent of tumor based on the Meigs- Brunschwing surgical staging, and they were significantly
higher in keratinizing type and large cell non - keratinizing type than those in small cell
type (p<0.05). Elevated serum TA-4 level returned to normal after complete tumor resection
so rapidly that 90% of cases showed normal values on second postoperative day and all
showed normal values on sixth postoperative day. These results indicate that (1) the specificity
of TA-4 is high. (2) there is some sensitivity of this antigen to cervical squamous cell carcinoma,
(3) it is of limited value to use this antigen for screening the disease. (4) but it would be a
useful tool in the detection of recurrence, in predicting the extent of disease and in monitoring
the response of tumor to therapy in patients with squamous cell carcinoma of the uterine
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College of Medicine/School of Medicine (의과대학/대학원)Dept. of Medicine (의학과)The Seoul Journal of MedicineThe Seoul Journal of Medicine Vol. 26 No.2 (1985)
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