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An Experimental Study on the Effect of Differential Ventriculomegaly on the Somatosensory Evoked Potential : 차등적 뇌실 확장이 체성감각 유발전위에 미치는 영향에 관한 실험적 연구

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Cho, Byung-Kyu; Wang, Kyu Chang; Lee, Yong Jin; Kim, Hyun Jip; Choi, Kil Soo

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Seoul National University College of Medicine
Seoul J Med, Vol.29 No.3, pp. 283-291
HydrocephalusDifferential ventriculomegalySomatosensory evoked potentialIncreased intracranial pressureCentral conduction timeVulnerability of cerebral cortex
Differential ventriculomegaly is encountered after head injury, craniectomy or
in some congenital hydrocephalic patients. The evoked potential studies have been widely
used for the functional evaluation of the neural tissue.
To evaluate the effect of ventriculomegaly on the somatosensory evoked potentials (SEP's)
and the effect of increased intracranial pressure (lCP) on SEP in ventriculomegaly, the
authors had recorded SEP in a differential ventriculomegaly model.
To make a differential ventriculomegaly model, twenty-eight cats had kaolin-injections
with cisternal puncture and hemicraniectomy. With the SEP studies of the cats in pre-hydrocephalic
phase, in post-hydrocephalic phase 4-8 weeks after kaolin-injection, and in increased
ICP phase, the effects of differential ventriculomegaly on the electrophysiologic
function of the brain were evaluated. The size of the ventricles were evaluated with brain CT
scan in 7 cats and with autopsy specimen in all 28 cats.
Intracranial kaolin-injection and hemicraniectomy produced asymmetrical ventriculomegaly
with the larger one on the hemicraniectomy side in 68%.
In pre-hydrocephalic and post-hydrocephalic phase studies with left-sided hemicraniectomy,
there were no significant side differences in the latencies. With the increased ICP,
there was a significant increase in the PI-Nl interpeak latency on the left side (pComparing pre- and post-hydrocephalic phases, the latencies of wave II increased significantly
in both sides (pof both sides. There was no significant influence of the differential ventriculomegaly on the
central conduction time (II-PI) of the SEP's with or without increased ICP. The differential
ventriculomegaly with increased ICP did prolong the early cortical transmission (PI-Nl) of
the SEP's on the left side (pcompared with that of the right side.
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