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Estradiol Dependency of Tumor Growth, Levels of Steroid Receptor Contents and Enzymic Activities in Rat Breast Cancer Tissues
흰쥐 유암의 estradiol 의존성 암성장에 따른 steroid 수용체 함량과 효소활성의 변화

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Authors
Park, Sang Chul; Yanq, Jung Hyun; Koh, Suk Hwan; Kim, Sao Tae; Lee, Jung Bin
Issue Date
1985-12
Publisher
Seoul National University College of Medicine
Citation
Seoul J Med, Vol.26 No.3, pp. 289-295
Keywords
Estradiol dependencyTumor growthSteroid receptorRat breast cancer
Abstract
To study the nature of tumor growth and regression, the mammary cancer
model in Sprague-Dawley rats, induced by N-nitrosomethylurea(NMU) was analyzed with a
view of biochemical response to physiological modification of host estradiol system, such as
ovariectomy, tamoxifen treatment or estradiol reinjection. The growth and regression of the
tumors were monitored by the tumor size variation in response to the treatment. The surgical
removal of estradiol generation system such as ovariectomy and the medical treatment of
estradiol antagonist, tamoxifen, markedly decreased the tumor size within two weeks, while the
replenishment of estradiol by intraperitoneal reinjection stimulated the tumor growth. With
these changes of tumor size, the efficiency of the functional hormonal apparatus was checked
by determination of the contents of the estradiol and progesterone receptor in the cytosol and
nuclear fractions, respectively. The receptor analysis showed that the contents of the cytoplasmic
estradiol and progesterone receptor varied directly in response to estradiol state of the
host namely, decreased level at reduced tumor volume and increased level at tumor-stimulated
state. The changing patterns of the contents of the nuclear estradiol and progesterone
receptors were similar to those of the cytoplasmic ones. In relation with the changes of
receptor contents, the radical-related enzymes were monitored for their activities such as
peroxidase, catalase, superoxide dismutase and glutathione transferase. Among them only the
peroxidase activities showed the positive correlation with the estradiol receptor contents. These
results indicated that the growth and regression of the mammary tumors could be deeply
related with the receptor status of estradiol system and the activities of peroxidase.
ISSN
0582-6802
Language
English
URI
https://hdl.handle.net/10371/6405
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College of Medicine/School of Medicine (의과대학/대학원)Dept. of Medicine (의학과)The Seoul Journal of MedicineThe Seoul Journal of Medicine Vol. 26 No.2 (1985)
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