S-Space College of Medicine/School of Medicine (의과대학/대학원) Dept. of Medicine (의학과) The Seoul Journal of Medicine The Seoul Journal of Medicine Vol. 26 No.2 (1985)
Effect of Milk Diet on Gastroduodenal Maiignancy Induced by N-methyl-N'-nitro-N-nitrosoguanidine in Rats
우유투여가 N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) 유발 위십이지장 암 발생에 미치는 영향에 관한 실험적 연구
- Han, Duck Jong; Kim, Jin-Pok; Kim, Yong Il
- Issue Date
- Seoul J Med, Vol.26 No.4, pp. 337-346
- An experimental study on the effect of a milk diet on carcinogenesis induced by
N-methyl-N-nitro-N-nitrosoguanidine (MNNG) was designed in rats to elucidate its mechanism.
A total of 136 Sprague-Dawley rats were divided into 6 groups according to the milk
dosages in each diet. The entire group of 136 rats was fed the MNNG (l00 ,u g/mll and milk
for the initial 28 weeks. Thereafter for the next 12 weeks the group was fed a normal diet
only. After this 40 week experiment 109 rats survived. These rats were then dissected with the
results being summarized as follows:
Suppression of gastroduodenal malignancy was evidenced by the increase of milk concentration
in the diet except for the group given MNNG and the lowest concentration of milk (6%
Significant differences in the rate of cancer association were present between the regenerative
hyperplasia (22.2%) and adenomatous hyperplasia (57.9%).
The incidence of benign lesions increased proportionally with the concentration of milk in
the diet, especially in regenerative hyperplasia.
In the group which had been given the lowest concentration of milk there was a significant
increase of the serum gastrin level in the rats with gastric cancer or precancerous benign
lesions like regenerative hyperplasia or adenomatous hyperplasia.