S-Space College of Medicine/School of Medicine (의과대학/대학원) Dept. of Medicine (의학과) The Seoul Journal of Medicine The Seoul Journal of Medicine Vol. 28 No.2 (1987)
Parental Chromosomal Abnormalities in 50 Couples with Recurrent Spontaneous Abortions
반복 유산력이 있는 50쌍의 부부에 있어서 양친의 염색체 이상에 관한 연구
- Moon, Shin Yong; Shin, Hee Chul; Chang, Yoon Seok
- Issue Date
- Seoul J Med, Vol.28 No.2, pp. 149-153
- Although the etiology of repetitive fetal wastage is unknown in many instances,
parental chromosomal rearrangements represent a well-established cause of repetitive spontaneous
abortions. And the frequency of parental translocations with recurrent spontaneous
abortions varies widely in reported series (4.7%-19.3%).
From January, 1980 to December, 1985, fifty couples with histories of two or more recurrent
abortions were evaluated cytogenetically with a GTG(G-band with Trypsin using Giemsa) technique.
The results were as follows:
1. In five (10%) of the couples with balanced translocations, four balanced carrier partners
(8%) were identified in husbands and one another (2%) in wives.
2. Pericentric inversion of the ninth chromosome were identified in two male partners (4%).
A high incidence (14%) of cytogenetic abnormalities were found in couples with recurrent
abortions. Chromosome analysis is advocated as a primary tool in the evaluation of couples
with repetitive fetal wastage.