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Parental Chromosomal Abnormalities in 50 Couples with Recurrent Spontaneous Abortions : 반복 유산력이 있는 50쌍의 부부에 있어서 양친의 염색체 이상에 관한 연구
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- Authors
- Issue Date
- 1987-06
- Citation
- Seoul J Med, Vol.28 No.2, pp. 149-153
- Keywords
- Chromosomal abnormalities ; Parental ; Recurrent abortion
- Abstract
- Although the etiology of repetitive fetal wastage is unknown in many instances,
parental chromosomal rearrangements represent a well-established cause of repetitive spontaneous
abortions. And the frequency of parental translocations with recurrent spontaneous
abortions varies widely in reported series (4.7%-19.3%).
From January, 1980 to December, 1985, fifty couples with histories of two or more recurrent
abortions were evaluated cytogenetically with a GTG(G-band with Trypsin using Giemsa) technique.
The results were as follows:
1. In five (10%) of the couples with balanced translocations, four balanced carrier partners
(8%) were identified in husbands and one another (2%) in wives.
2. Pericentric inversion of the ninth chromosome were identified in two male partners (4%).
A high incidence (14%) of cytogenetic abnormalities were found in couples with recurrent
abortions. Chromosome analysis is advocated as a primary tool in the evaluation of couples
with repetitive fetal wastage.
- ISSN
- 0582-6802
- Language
- English
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