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Prognostic Evaluation of Acute Lymphoblastic Leukemia by Immunologic Markers
면역학적 표지에 의한 급성 림프아구성 백혈병의 예후판정

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Issue Date
1987-06
Publisher
Seoul National University College of Medicine
Citation
Seoul J Med, Vol.28 No.2, pp. 115-123
Keywords
Acute lymphoblastic leukemiaPrognosisOKT10c/T ALL
Abstract
Leukemic blasts from 128 consecutive patients (68 children and 60 adults) with
acute lymphoblastic leukemia(ALU were tested in each case for the following surface markers:
sheep erythrocyte receptortf.-R), TI0 antigerul l O), surface membrane immunoglobulin(Smlg)
and common' ALL antigen(CALLA). A clear distinction of 5 subgroups of patients with ALL was
possible: (1) common null-cell or cALUCALLA+) in 47 patients; (2) intermediate-cell or ciT
ALL (CALLA+, TI0+) in 29 patients; (3) T-cell or T-ALUE-R -: in 21 patients; (4) null-cell
or null ALL in 29 patients; and (5) 8-cell or B-ALL (Srnlg-j ) in 2 patients. Particular emphasis
was put on the subgroup with TI0 expression together with CALLA. An analysis of clinical
data at presentation revealed significant differences for white-cell count, age distribution and
organomegaly between cALL and ciT ALL. There were also significant differences in freuqencies
of remission induction and survival rate between cALL and ciT ALL. TI0 positivity is a
poor prognostic factor in common ALL. We evaluated prognostic significance of the markers by
univariate and multivariate survival analysis and concluded that a combined use of the markers
is essential to reach a precise diagnosis of subgroups of ALL with different biologic and
prognostic characteristics.
ISSN
0582-6802
Language
English
URI
https://hdl.handle.net/10371/6423
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College of Medicine/School of Medicine (의과대학/대학원)Dept. of Medicine (의학과)The Seoul Journal of MedicineThe Seoul Journal of Medicine Vol. 28 No.2 (1987)
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